Indianapolis is 6-1, but only two of the wins were against teams with current records above .500, and it will be asking a lot for the Colts to cover a two-touchdown spread as they look ahead to a big game at Pittsburgh next week. Tennessee has a game under its belt with interim head coach Mike McCoy, and we can expect some improvement since the first meeting when the Colts won 41-20 in Week 3. The Titans come off a loss to New England, but Cam Ward showed some promise, finishing 25 of 34 for 255 yards and a TD with one interception. However, Tennessee needs to get its ground game going, as it rushed for just 39 yards. Nevertheless, the Colts showed vulnerability in their pass defense as Justin Herbert torched it with 37 completions for 423 yards and three TDs last week, although with two interceptions. Indianapolis is 3-11 ATS in its past 14 games as a favorite of more than three points against teams off a double-digit loss, and the Colts are 0-9 ATS after scoring at least 35 points in their previous game. Take the Titans.
This pick was released to clients on October 24, 2025 at 10:03AM ET.
Tennessee at Indianapolis
October 26, 2025
2 units on Tennessee +15.5 (-110) (risk 2 to return 3.82)
Result:
LOSS
LOSS
TAKE THE GUESSWORK OUT OF SPORTS BETTING
Get $50 of premium NFL picks free.
Join 410,360 Subscribers!