Well-coached Tennessee was the AFC's No. 1 seed last year but is a huge underdog. They also have an above-average QB in Ryan Tannehill (2 TDs, 0 INTs) and a balanced attack anchored by RB Derrick Henry. Henry had the best game of any back against the Bills' defense last year with 172 yards rushing (7.2 ypc) and 3 touchdowns in a 34-31 Titans win over Buffalo. NFL underdogs like the Titans that averaged 24+ points in the previous season are 44-21 ATS. Buffalo returns home from the West Coast after a Week 1 win at Los Angeles. The Buffalo offense wasn't in mid-season form turning it over 4 times and has a new offensive coordinator in Ken Dorsey after Brian Daboll left to run the Giants. They rebuilt the defensive line after a playoff loss to Kansas City letting go of six veterans. The defense will be without injured DTs Ed Oliver and Tim Settle tonight and the underdog is 10-1 ATS when these teams clash. Play Tennessee.
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