These Pro Picks were released to clients on November 15, 2025 at 11:51AM ET.
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Tampa Bay at Buffalo

November 16, 2025
img1:00 PM Eastern

Buffalo came out flat after its big win over Kansas City, and the Bills inexplicably were routed by the lowly Dolphins 30-13. That is reason enough to believe the Bills will bounce back after such a performance, especially on their home turf. Tampa Bay is 1-6-1 ATS in its past eight games on turf, and the temperature is expected to be in the upper 30s with possible rain and heavy winds, which obviously won't be in the Buccaneers' favor. Tampa Bay has lost five of its past six November games, while Buffalo has won 14 of its last 15 home games. The Bills are 16-4 straight up in their past 20 against the NFC. Buffalo has gone UNDER four of five, and it is 6-0 UNDER after totaling fewer than 90 yards rushing in its previous game. The Bills are 4-0 UNDER after allowing more than 350 total yards in their last game. The Buccaneers come off a 28-23 loss to New England while yielding 166 yards rushing on 6.1 yards per carry. Take the Bills on the moneyline and the UNDER. 

1 unit on Buffalo -250 (moneyline) (risk 1 to return 1.4)
Result:
WIN
2 units on Game Total UNDER 47.5 -110 (risk 2 to return 3.82)
Result:
LOSS
Final
1
2
3
4
F
Tampa Bay Buccaneers
3
17
6
6
32
Buffalo Bills img
7
14
10
13
44
consensus consensus
odds odds
 
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