Seattle at San Francisco

San Francisco has dominated this series, winning seven of the past eight meetings, including a 17-13 road win over Seattle in the opening week. The 49ers have overcome key defensive injuries to average 34.2 points per game in their last eight games. Christian McCaffrey is having a monster season, rushing for 1,179 yards and catching 96 passes for 890 yards while accounting for 17 touchdowns. Brock Purdy has the fourth-highest quarterback ranking in the league. These are players that can be trusted. Not so with Seattle quarterback Sam Darnold. This game decides the NFC West Division. Darnold does not have a good history in big games. He has been intercepted four times in his last four outings. Darnold has been picked off 14 times this season. That is the most in the NFC. Darnold could be missing his No. 2 wide receiver, Rashid Shaheed, who has a short week to clear concussion protocols after leaving Week 17’s game against the Panthers. Take the 49ers on the moneyline.