San Francisco at New York

San Francisco has allowed an average of 25 points in its last four road games. In their previous two road contests, they lost to Houston (26-15) and Tampa Bay (30-19). Mac Jones (8 TDs, 5 INTs) has been filling in for QB Brock Purdy, who may be able to return this week. The defense ranks 22nd in yards allowed and 19th on third down (38.95%). The 49ers are 8-4 OVER the total in their last 12 road contests. New York's defense ranks 29th in yards allowed, 30th against the run, and 27th in points allowed (26.9 per game). They come home from a two-game road trip, scoring 52 points but losing both, allowing 33 and 38 points. Take San Francisco/New York OVER the total.