This Pro Pick was released to clients on October 02, 2025 at 12:05PM ET.
img NFL

San Francisco at Los Angeles

October 2, 2025
img8:15 PM Eastern

For a 3-1 team, San Francisco has some ugly numbers. QBs Brock Purdy and Mac Jones have combined for eight touchdowns and five interceptions, while the ground game averages a measly 3.3 yards per carry. They have a close win over the worst team in the NFL, New Orleans, 26-21, and squeezed by Arizona (16-15). Some flaws were exposed on Sunday in a 26-21 home loss to Jacksonville, as the team turned the ball over four times. The 49ers are without two of their top three wide receivers in Ricky Pearsall (knee injury) and Jauan Jennings (rib injury) and now Brock Purdy has been officially ruled out. Los Angeles also has just one loss, a close one to defending champion Philadelphia, along with a 27-20 victory over the 3-1 Colts as QB Matthew Stafford (8 TDs, 2 INTs) threw for 375 yards. The offense has balance with RB Kyren Williams (303 yards, 4.5 ypc), anchoring a ground attack that averages 4.5 yards per carry. The defense ranks ninth in the NFL in yards allowed, 10th in points allowed, and sixth in third-down conversions (34%). The Rams are 2-0 at home, with the wagering value on the home team to win the game. While it's unclear if they are gonna cover this very large number, I like LA on the moneyline. I realize it's a steep price, but hey, who am I to sniff at a 24% ROI in one day, which is what a win at these odds will pay out? That compares very nicely to the 0.02% stock market average daily return. It's a 120x higher payout to be precise. Play Los Angeles on the moneyline. 

2 units on Los Angeles -410 (moneyline) (risk 2 to return 2.49)
Result:
LOSS
Final - OT
1
2
3
4
O
F
San Francisco 49ers img
7
10
3
3
3
26
Los Angeles Rams
0
7
7
9
0
23
consensus consensus
odds odds
 
TAKE THE GUESSWORK OUT OF SPORTS BETTING

Get free NFL Picks

I pore over the data, injuries, news, and odds every morning.
You get the best bets delivered to your inbox.