San Francisco at Houston

San Francisco has split its last four games after starting 3-0. The 49ers have been dealing with a lot of injuries, down to backup QB Mac Jones (6 TDs, 4 INTs), along with a running game that is 25th in rushing yards while averaging just 3.3 yards per carry. They were beaten in their last road game, 30-19, at Tampa Bay. Jones was sacked six times and had no touchdowns and two interceptions. Houston has a +39 point differential, the fourth-best in the AFC, despite playing four road games and only two at home. QB C.J. Stroud (9 TDs, 4 INTs) leads the offense, while the defense is fourth in yards given up, fourth on third down (32%), and No. 1 in points allowed (14.9 per game). The wagering value is on the home team to win the game. Play Houston on the moneyline.