San Francisco at Detroit

The San Francisco 49ers are off a losing season while decimated by injuries, but this is a talented group that has Super Bowl aspirations and the public knows that. It's a ball-control, run-oriented offense behind QB Jimmy Garoppolo. They can do that because the defense is outstanding, fifth in the NFL in total yards allowed in 2020 even though Nick Bosa, Dee Ford, and cornerback Richard Sherman combined to miss 40 games with injuries, and the defensive line features four first-round picks. Detroit has a new offensive playbook with first-year coach Dan Campbell and a new QB in Jared Goff (42 TDs, 29 picks the last two seasons). The Lions went heavy in the offseason to upgrade a terrible defensive line in adding defensive tackle Michael Brockers with draft picks DT Levi Onwuzurike and NT Alim McNeill. They join CB Jeffrey Okudah, a Top 5 pick two years ago. This is a ton of points for a home team to get against a solid quarterback. The home crowd should be pumped here. Favorites coming off a losing season in conference games do not perform well against the spread. San Francisco is 7-0 to the UNDER in week one the past seven seasons. Also, the UNDER is 6-2-1 when these teams clash, and this looks like another Week 1 defensive duel. Take the Lions with the points and back the UNDER.