Los Angeles coach Jim Harbaugh is 13-9 in the preseason. He has a 2-1 record this preseason and is a combined 8-1 in Weeks 3 and 4. The offense has averaged 27.25 points in its last four August contests. Chargers QB Trey Lance has played well and has been motivated, the third overall pick in the 2021 NFL draft. Speaking of motivation, he's facing the team that drafted and gave up on him in this one. The San Francisco defense has given up 30 and 19 points in two games. The 49ers gave up 30 points in their only preseason home game in 2025, a loss to Denver, surrendering 368 yards (153 rushing). Play Los Angeles + OVER the total.
These Pro Picks were released to clients on August 22, 2025 at 11:26AM ET.
NFL
Los Angeles at San Francisco
August 23, 2025
8:30 PM Eastern
1.5 units on Los Angeles -1.5 (-110) (risk 1.5 to return 2.86)
Result:
LOSS
LOSS
1 unit on Game Total OVER 34.5 -119 (risk 1 to return 1.84)
Result:
WIN
WIN
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