Jacksonville has won six in a row behind QB Trevor Lawrence (26 TDs, 11 INTs), averaging 34.1 points. They come off a 34-20 win at Denver, one of the best defensive teams in the league. The Jaguars are on an 8-4 run OVER the total, including 6-1 OVER on the road. Indianapolis plays its second straight at home, after a 48-27 loss to San Francisco. New QB Philip Rivers threw for 277 yards and two touchdowns. The defense is 25th in yards allowed, with the Colts on a 5-2 run OVER the total at home. Take Jacksonville/Indianapolis OVER the total.
This Pro Pick was released to clients on December 26, 2025 at 10:12AM ET.
NFL
Jacksonville at Indianapolis
December 28, 2025
1:00 PM Eastern
2 units on Game Total OVER 48 -110 (risk 2 to return 3.82)
Result:
LOSS
LOSS
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