Arizona comes off two losses to Seattle and San Francisco, but it's not QB Jacoby Brissett's fault. He completed an NFL-record 47 passes for 452 yards and two TDs against the 49ers. Unfortunately, the Cardinals were called for a franchise-record 17 penalties. They are 6-1 ATS in their past seven games after allowing at least 30 points in their previous game. The Cardinals are 19-7-1 ATS after totaling fewer than 90 yards in their last game. Arizona is 8-1 ATS in its past nine against AFC opponents. Jacksonville is on a 2-18 ATS run versus NFC West teams, and although the Jaguars routed the Chargers while staying UNDER last week, they are 1-3-1 ATS their past five games. Arizona has gone UNDER in four of its past six November games, and the Cardinals are 2-9-1 UNDER as underdogs of nine or fewer points against opponents at .500 or above. Look for Arizona to cut down on its mistakes and give its defense a better chance. Take the Cardinals and the UNDER.
These Pro Picks were released to clients on November 21, 2025 at 10:58AM ET.
Jacksonville at Arizona
November 23, 2025
1.5 units on Arizona +3 (-110) (risk 1.5 to return 2.86)
Result:
PUSH
PUSH
2 units on Game Total UNDER 47.5 -107 (risk 2 to return 3.87) Game of the Week
Result:
LOSS
LOSS
TAKE THE GUESSWORK OUT OF SPORTS BETTING
Get free NFL Picks
I pore over the data, injuries, news, and odds every morning.
You get the best bets delivered to your inbox.