These picks were released to clients on September 19, 2025 at 9:45AM ET.
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Indianapolis at Tennessee

September 21, 2025
img1:00 PM Eastern

Indianapolis was fortunate, to say the least, to pull off a 29-28 win over Denver, which was penalized for leverage, allowing Spencer Shrader to kick a 45-yard field goal after he missed a 60-yard try that was nullified. The Colts are 1-4 ATS in their past five road games, and they have gone UNDER in five straight Week 3 games. Four of the past six meetings have gone UNDER. Tennessee has a demanding early schedule, but the Titans have kept things relatively close while losing to the Broncos and Rams. Tennessee trailed 17-16 at the end of three quarters before Los Angeles outscored it 13-3 in the fourth. Cam Ward was more than adequate, completing 19 of 33 for 175 yards and a TD with no interceptions, and Tony Pollard ran for 92 yards on 20 carries. The Titans are 6-0-1 ATS in their past seven games following a double-digit home loss. The offensive line has been a problem for Tennessee, with Ward being constantly pressured. However, the Colts haven't had much of a pass rush in the early going this season. Indianapolis goes on the road for the first time, and it is 2-11 ATS as a favorite of more than three points against a team off a double-digit loss. Take the Titans and the UNDER.

2 units on Tennessee +4.5 (-115) (risk 2 to return 3.74)
Result:
LOSS
1 unit on Game Total UNDER 43.5 -107 (risk 1 to return 1.93)
Result:
LOSS
Final
1
2
3
4
F
Indianapolis Colts img
17
3
14
7
41
Tennessee Titans
3
3
7
7
20
consensus consensus
odds odds
 
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