Indianapolis at Los Angeles

Indianapolis is 3-0 and off to its best start since 2009, and the Colts are 5-0 ATS in their past five September games. Los Angeles is 1-6 ATS in its past seven Week 4 games. The Colts come off a 41-20 victory over Tennessee with Jonathan Taylor rushing for 102 yards and three TDs. Cornerback Kenny Moore returned an interception 32 yards for a TD on the game's third offensive play, and the Colts easily went OVER for the second game in a row and seventh in eight games dating to last season. Indianapolis is 5-0 OVER its past five road contests. The Rams are 5-1 OVER their past six September games and 6-1 OVER against teams with winning records. Daniel Jones continues to impress, finishing 18 of 25 for 228 yards and a touchdown against the Titans. The Rams might need more than a week to recover from an unbelievable 33-26 loss at Philadelphia. They first blew a 26-7 lead and then lost the win and cover on a blocked kick that was returned for a touchdown by 336-pounder Jordan Davis. The game soared OVER by 13.5 points. The Colts are averaging 34.3 points this season. Indianapolis has a solid secondary with 13 pass deflections and four picks this season. Take the Colts and the OVER.