Indianapolis is unbeaten at home but 2-2 on the road. They come off a bye week after beating the Falcons in Germany, 31-25 in overtime. This will be their third straight away from home, including a 27-20 loss at Pittsburgh, where they turned it over six times. QB Daniel Jones has six touchdowns and six interceptions in his five games away from home (counting the European game) and has been limited in practice this week with a calf injury. The Colts are on a 5-8 straight-up run on the road. Kansas City has a great urgency for a strong effort after losing the last two games, both on the road, at Buffalo (28-21) and Denver (22-19). Teammates describe QB Patrick Mahomes (18 TDs, 6 INTs) as being focused and locked in this week, demanding sharper practices and more clarity in meetings. "We've got a sour taste in our mouth about the Denver game," added one player. Kansas City has won 12 of its last 13 at Arrowhead. Given the wagering value on the home team to win, I'm backing Kansas City on the moneyline.
This Pro Pick was released to clients on November 21, 2025 at 10:58AM ET.
Indianapolis at Kansas City
November 23, 2025
2 units on Kansas City -175 (moneyline) (risk 2 to return 3.14)
Result:
WIN
WIN
TAKE THE GUESSWORK OUT OF SPORTS BETTING
Get free NFL Picks
I pore over the data, injuries, news, and odds every morning.
You get the best bets delivered to your inbox.