It's a battle for first place in the AFC South, and Indianapolis will look to bounce back from three close losses in its past four games, including 20-16 to Houston on Sunday, when the Colts were held to fewer than 20 points for the first time this season. Daniel Jones was 14 of 27 passing for 201 yards and two TDs while playing through a lower leg injury, although he says it is improving each week. The Colts' defense has been overlooked as they allow 20.8 points per game. Indianapolis is 7-2 ATS in its past seven games against AFC opponents. Jacksonville is on a three-game win streak, but the last two were against Arizona and Tennessee, who combined for a 4-20 record. The Jaguars have gone UNDER six of their past seven home games, and they are 7-1 UNDER their past eight December games. Curiously, Indianapolis is still the slight favorite on the road even after its recent losses, which suggests the oddsmakers see this matchup differently. Take the Colts and the UNDER.
These picks were released to clients on December 05, 2025 at 12:33PM ET.
Indianapolis at Jacksonville
December 7, 2025
1 unit on Indianapolis -1 (-120) (risk 1 to return 1.83)
Result:
LOSS
LOSS
1.5 units on Game Total UNDER 47.5 -105 (risk 1.5 to return 2.93)
Result:
LOSS
LOSS
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