Indianapolis at Houston

Indianapolis flopped in the finale last year, losing to the worst team in the league, Jacksonville, which stopped them from making the playoffs. So the worst owner in the NFL (Jim Irsay) went out and got 37-year-old QB Matt Ryan. And here they are a huge road favorite in Week 1. It's a run-oriented offense behind RB Jonathan Taylor, as Ryan has a relatively young group of wide receivers and tight ends to work with. There are also two new starters on the offensive line. The defense has a new coordinator in Gus Bradley on a unit that was #16 in yards surrendered, #18 on third down, and the eighth-worst in sacks. The Colts are 3-12-1 ATS in Week 1. Trading QB Deshaun Watson gave Houston a rebuilding boost with two of the Top 15 picks and two more second-round selections for head coach Lovie Smith. The West Coast ball-control offense uses power run-blocking schemes with multi-tight end packages and gets a big addition in guard Kenyon Green (15th overall pick) joining left tackle Laremy Tunsil. In the offseason, the front office made the priority upgrading the secondary, which they did. With far less talent, the Texans played hard at home last season with a 25-22 loss to the Patriots, a 37-21 win over Jacksonville, a 21-14 loss to the Jets, a 41-29 upset of the Chargers, and a 28-25 loss to Tennessee. Play Houston.