Indianapolis at Buffalo

The Indianapolis Colts have nothing to prove in Preseason Week 1 and they aren't going to risk an injury to often-injured star QB Andrew Luck. Coach Frank Reich has already ruled Luck out for this game. The backups are one-dimensional Jacoby Brissett, Chad Kelly and Phillip Walker. In two road preseason games last year the defense allowed 21.5 points per game. They face a young Buffalo squad that is home and added a lot of talent, including WRs Cole Beasley and John Brown, center Mitch Morse, two-way TE Tyler Kroft and defensive tackle Ed Oliver with the ninth pick of the draft. The Bills had the No. 2 defense in efficiency last year, ranking #14 versus the run and second against the pass. Look for a big effort by the home team against the disinterested visitors. Play Buffalo.