Denver at San Francisco

Denver has won three straight, but it's still less than a touchdown favorite against the 2-10 49ers. That is due to the possibility of it being a flat spot for the Broncos after a big home win over Pittsburgh and then winning on the road 24-10 at Cincinnati. Rookie Phillip Lindsay rushed for a career-high 157 yards and two touchdowns and Case Keenum completed 12-of-21 passes for 151 yards. San Francisco quarterback Nick Mullens finished 30-of-48 for 414 yards, but the Niners couldn't get their running game going, rushing for only 66 yards on 2.9 per carry. Still, Mullens performed well considering Seattle is one of the toughest places to play and now he gets another chance at home. The Broncos are 5-12-1 ATS their last 18 games after allowing 15 or fewer points in their previous game and San Francisco has covered the number five of its last seven December games. Surprisingly, these teams have similar offensive statistics with Denver averaging 365.7 total yards and 23.0 points compared to 363.2 and 21.2 for the 49ers. The points loom large in this matchup, so take the 49ers.