Denver at Philadelphia

Denver has lost its past five road games both straight up and ATS, and now the Broncos have to go on the road and play the defending Super Bowl champions. Philadelphia has won 10 in a row and 20 of its last 21 games, while escaping some close contests this season. The Eagles' margin of victory in 2025 is only 4.75 points. They led Tampa Bay 24-3 in the second quarter and hung on to win 31-25 when Baker Mayfield was intercepted on first down from the Philadelphia 11 in the fourth quarter. The Broncos took advantage of Joe Burrow's absence and beat Cincinnati 28-3, but this week they'll have to deal with Jalen Hurts, who threw two TD passes to end Dallas Goedert tight, and went 15-for-24 for 130 yards while rushing for 62 yards on nine carries. The Eagles have won 12 straight home games. Denver allows 99.3 rushing yards per game, and Saquon Barkley is due to break out after averaging 59.3 yards in his first four games. Take the Eagles on the moneyline.