Denver suffered a heartbreaking loss to the Colts, but they will look to bounce back against the Chargers, who are coming off two huge divisional wins and now have to go for a third. The Chargers have lost eight of their past 10 Week 3 games. They are 10-2 UNDER when playing at home against the Broncos. Bo Nix did his part on Sunday with 206 yards and three TDs for the Broncos, who also rushed for 118 yards on 24 carries. Los Angeles beat the Raiders 20-9, but left a lot of points on the field when they didn't take much advantage of three Geno Smith interceptions. The Chargers finished with 81 rushing yards on 3.1 per carry, and the game stayed UNDER by 17.5 points. Los Angeles is 9-0 UNDER off a divisional road win. This is a double-revenge game for Denver, which lost both meetings last year. Take the Broncos and the UNDER.
These Pro Picks were released to clients on September 19, 2025 at 9:45AM ET.
Denver at Los Angeles
September 21, 2025
2 units on Denver +3 (-118) (risk 2 to return 3.69)
Result:
PUSH
PUSH
1.5 units on Game Total UNDER 46 -107 (risk 1.5 to return 2.9)
Result:
WIN
WIN
TAKE THE GUESSWORK OUT OF SPORTS BETTING
Get free NFL Picks
I pore over the data, injuries, news, and odds every morning.
You get the best bets delivered to your inbox.