Denver shut down Tennessee in the opener at home, 20-12. Now they head out for their first road game. The offense turned it over four times. Denver was 6-2 at home last season, but had a losing road record. In 2023, they also had a winning home record but a losing road mark. The Broncos are on a 1-4 ATS run, including 0-3 ATS on the road. Indianapolis plays its second straight at home after crushing the Dolphins, 33-8. QB Daniel Jones threw for 272 yards while the ground attack had 156 yards. The defense allowed 211 total yards under new coordinator Lou Anarumo. The Colts are on a 6-3 ATS run at home. Play Indianapolis.
This Pro Pick was released to clients on September 12, 2025 at 9:49AM ET.
NFL
Denver at Indianapolis
September 14, 2025
4:05 PM Eastern
1.5 units on Indianapolis +1.5 (-105) (risk 1.5 to return 2.93)
Result:
WIN
WIN
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