An AFC East showdown between the two best teams. Buffalo RB James Cook III leads an attack that averages 5.1 yards per carry and 157.8 yards per game, both tops in the NFL. The Bills have averaged 32 points in the last four games. The defense is 10th in yards given up. New England's run defense is banged up with injuries, without DT Milton Williams, while Khyiris Tonga missed the Patriots' most recent game with a chest injury. And the offensive line has dealt with a lot of key injuries down the stretch. Play Buffalo on the moneyline.
This Pro Pick was released to clients on December 12, 2025 at 11:58AM ET.
NFL
Buffalo at New England
December 14, 2025
1:00 PM Eastern
2 units on Buffalo -114 (moneyline) (risk 2 to return 3.75)
Result:
WIN
WIN
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