Buffalo at Jacksonville

Buffalo is a cold-weather team heading to the warm, humid Florida climate. They also have a division game on deck and are banged up on the offensive line. Guard Jon Feliciano (calf strain) is questionable along with left tackle Spencer Brown (back injury), who didn't play last week. This is their third road game in four contests, and they're a huge favorite. NFL road favorites that are outscoring opponents by 10+ on the season are 19-47 ATS after a win by 10+ points. Jacksonville prefers to run the football under first-year coach Urban Meyer, and the team gets No. 1 RB James Robinson back after he missed most of last week's game. Jacksonville is playing hard for this coaching staff, losing 24-21 at Cincinnati as a +7 dog, losing two home games by 10 and 12 points, along with an upset of Miami, 23-20. With the Bills 15-29 ATS off an AFC East win by 10+ points, plus 15-31 ATS off a home win against a division rival, back the huge home dog. Play Jacksonville.