Buffalo at Chicago

Buffalo coach Sean McDermott has a winning preseason record, including 5-2 straight-up in Week 2. The Bills are a deep, talented team that has been to the playoffs for six straight years. A year ago, the Bills showed nothing in the opener, but won at Pittsburgh in Week 2, 9-3, in their only road exhibition contest as a +2.5 underdog. They're 5-1 straight-up in their last six Week 2 August games, beating Denver (42-15), winning at Chicago (41-15), winning at Carolina (27-14), and at Cleveland (19-17). Chicago has a new coach and playbook under first-year coach Ben Johnson. They come off a 24-24 tie at home against Miami, allowing five sacks. The ground game had just 90 yards on 3.8 yards per carry. Play Buffalo on the moneyline.