Arizona comes off a huge confidence-builder, defeating the Cowboys 27-17 on Monday night after losing five close games in a row. The Cardinals are much better than their record indicates, and Jacoby Brissett will get the start again after throwing for 261 yards and two TDs with no interceptions. Emari Demercardo rushed for 79 yards on 5.6 per carry. The defense also came up big with some clutch plays in the second half. The Cardinals have covered their last five road games, and they are 8-0 ATS on the road against teams with winning home records dating back to last season. Seattle is 2-9-2 ATS after allowing fewer than 150 yards passing in their previous game. The Seahawks are 2-8 ATS their past 10 after a win by more than 14 points, and they are 5-1 OVER following a win. Also, Seattle has gone OVER four of five home games and five of seven overall. Arizona is in a revenge spot after losing the first meeting 23-20. Take the Cardinals and the OVER.
These Pro Picks were released to clients on November 07, 2025 at 11:06AM ET.
Arizona at Seattle
November 9, 2025
1 unit on Arizona +7 (-108) (risk 1 to return 1.93)
Result:
LOSS
LOSS
2 units on Game Total OVER 44.5 -115 (risk 2 to return 3.74)
Result:
WIN
WIN
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