The first meeting, on September 20 in Arizona, ended 31-7. Seattle ran 40 times for 162 yards and held the ball for 36:33, while the Cardinals finished with 151 total yards on 47 plays. Drew Lock was Seattle's quarterback that day, going 19-of-26 for 235 yards and three touchdowns. He starts Sunday again because coach Mike Macdonald ruled out Sam Darnold with a quad injury. Lock was limited by an elbow injury on every report from Week 6 through Week 8 and spent the past two games as the emergency third quarterback. Seattle allowed 33 at Washington on September 27 and 34 to Chicago last Monday. Arizona scored 7 against this defense in Week 2 and averaged 20.3 points per game in its first seven games, before the Dallas game. Gardner Minshew replaced Jacoby Brissett during last week's win over Dallas and now starts against a defense that held New England to 10 in the opener. I expect Seattle to lean on the run again with a quarterback working back from an elbow injury, and that keeps the clock moving and Arizona's possessions few. Take the UNDER on Sunday.
This Pro Pick was released to clients on November 06, 2026 at 10:51AM ET.
Arizona at Seattle
November 8, 2026
1 unit on Game Total UNDER 40.5 -120 (risk 1 to return 1.83)
Result:
WIN
WIN
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