Arizona starts the season with a long road trip. In 2024, they were 6-3 at home but 2-6 on the road. The Cardinals have revamped their defense, one that was 20th in yards allowed. They've lost their last four on the road. New Orleans has deep threats to attack that defense in L. Rashid Shaheed and Brandin Cooks. New Orleans won its first two games last year, 47-10 and 44-19. The Saints have also won their last six season openers, the longest active streak in the NFL. Play New Orleans.
This Pro Pick was released to clients on September 05, 2025 at 10:25AM ET.
NFL
Arizona at New Orleans
September 7, 2025
1:00 PM Eastern
2 units on New Orleans +6.5 (-108) (risk 2 to return 3.85)
Result:
LOSS
LOSS
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