The Rams are mere mortals after all. That was proven last week when their six-game winning streak came to a crashing halt with a turnover-filled, 31-28, loss to the Panthers. The Cardinals defeated the Panthers, 27-22, at home back in Week 2. Arizona buried the Rams, 41-10, in the desert last season. So this is far from a given that the Rams will automatically bounce back by covering this large road number. Matthew Stafford is having an MVP-type season, but Arizona edge rusher Josh Sweat can make it rough on him. Sweat has 11 sacks. That is tied for the fourth most in the NFL. Cardinals quarterback Jacoby Brissett has put up Stafford-type numbers since replacing injured Kyler Murray seven games ago. Brissett has four 300-yard passing games this season, which is tied for the NFL lead. He has thrown for at least 300 yards in three consecutive games, including 301 in last week's loss to the Buccaneers. The Cardinals won't be going to the playoffs. But they would be 10-2 if given this many points. Take the Cardinals.
This Pro Pick was released to clients on December 05, 2025 at 12:33PM ET.
Los Angeles at Arizona
December 7, 2025
1 unit on Arizona +9 (-120) (risk 1 to return 1.83)
Result:
LOSS
LOSS
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