Last-place Arizona has lost five in a row, averaging 20.4 points. In their last three road games, the Cardinals have averaged 18.6 points. Houston has a powerhouse defense ranked No. 1 in the NFL in points allowed (16 per game) and total yards allowed (266.3 yards per game). Houston is 10-3 UNDER the total this season, part of a 14-6 run UNDER. Take Arizona/Houston UNDER the total.
This Pro Pick was released to clients on December 12, 2025 at 11:58AM ET.
NFL
Arizona at Houston
December 14, 2025
1:00 PM Eastern
2 units on Game Total UNDER 42.5 -108 (risk 2 to return 3.85)
Result:
LOSS
LOSS
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