Carolina comes off a 30-27 win over Atlanta as QB Bryce Young threw for 448 yards. The Panthers are one of the four remaining teams that have yet to take their bye week, and have a chance to take over sole possession of the top spot in the NFC South tonight, but the Niners will have something to say about that. San Francisco got QB Brock Purdy back last week, and he led the team to 488 yards in a 41-22 victory over Arizona. Their injury-riddled defense ranks 26th in yards allowed and 30th on third down (40.77%), on a 7-3 run OVER the total. The 49ers are in the playoff hunt despite playing seven road games and only four home contests. Carolina's defense is allowing 23.5 points per game on the road and ranks 18th in total yards allowed and 30th on third downs (43.4%). The Panthers are on an 18-7 run OVER the total, and will struggle to contain Kyle Shanahan's resurgent offense. I'm going with a 2-team parlay pick for this contest: Combine the 49ers (-370 ML) and the OVER 49.5 into a 2-team parlay at +144 odds.