San Francisco has won four in a row and ranks 10th in the NFL in total yards and points (24.6 per game). The defense has allowed 15.75 points per game during this four-game winning streak. Due to devastating injuries, Indianapolis has been forced to start QB Philip Rivers. After a long hiatus, it's clear his arm strength isn't there. They come off an 18-16 loss to Seattle, with the offense averaging 17 points over the last three games. The Colts have lost four in a row, and are on a 4-2 run UNDER the total.

Combine the 49ers (-240) and the San Francisco at Indianapolis UNDER 46.5 (-115) into a 2-team parlay at +165 odds.