New York Giants vs San Francisco 49ers

New York got some much-needed momentum heading into this game by overcoming a 21-point third-quarter deficit and defeating Arizona 31-28 when Graham Gano kicked a 34-yard field goal with 19 seconds left. Daniel Jones redeemed himself after a disastrous Week 1 performance, completing 26 of 37 passes for 321 yards and two TDs for the Giants. Saquon Barkley (ankle) likely won't play against San Francisco, and the backups are Matt Breida and Gary Brightwell. The 49ers are 2-9 ATS their past 11 games in Week 3 and 4-9 ATS overall in Thursday games, including 1-6 ATS coming off a win. The Giants are 20-8 ATS as road underdogs of 3.5-10.5 points and they have covered eight of 11 overall on the road. Brock Purdy passed for 206 yards and ran for a TD, but the 49ers showed some vulnerability on defense as the Rams outgained them 386-365. Rookie wide receiver Puka Nacua had 15 catches for 147 yards to break the NFL's single-game receptions record for a rookie. The Niners are by far the superior team, but this is too many points. Take the points with the Giants as a Max Play.

San Francisco gets a break, not having to travel to the East Coast again for this game as it played on the same field last week in a 31-13 win over the Jets. The 49ers probably wish they were playing somewhere else, though, as they suffered numerous injuries on Sunday, attributing it to the turf. New York has some problems on offense as it has scored only 29 points its first two games, and the Giants lost Saquan Barkley for the season with a torn ACL. New York also placed wide receiver Sterling Shepard on injured reserve with a toe injury so their problems rival the Niners. Nick Mullens will likely start for San Francisco after Jimmy Garoppolo went down with an ankle injury. Mullens started eight games for San Francisco in 2018 and finished with a 90.8 QB rating while completing 64.2 percent of his passes. Mullens threw for 2,277 yards and 13 touchdowns that season. The posted total is relatively low and the Giants faced two good defenses their first two games. The OVER is 8-3-1 in the Niners' last 12 games vs. NFC teams and they are 8-3-1 OVER as favorites. The Giants are 11-5 OVER following a loss and the Giants have gone OVER six years in a row in Week 3. Play the 49ers on the moneyline and the OVER.

This is not exactly a marquee Monday Night matchup as the teams have the second-lowest combined winning percentage (.176) for an MNF game played in November or later in NFL history. San Francisco has one potential bright spot as Nick Mullens played well in his first career start, but that's not much for a 2-7 team that is laying points. The 49ers had lost their previous six games and they are #20 in the league in total yards of offense as they keep going through quarterbacks with Jimmy Garoppolo (torn ACL) and C.J. Beathard (concussion) both out. Eli Manning again will try to get his team a win after close losses to Atlanta and Washington. The Giants come off a bye week and have had plenty of time to prepare for this one. Manning was 30-of-47 for 316 yards with a touchdown and two interceptions against the Redskins, but the Giants need to get Saquon Barkley in the mix as he carried 13 times for only 38 yards. New York is 5-0 ATS its last five games after scoring fewer than 15 points its previous game and 7-2 ATS its last nine following an ATS loss. San Francisco is 5-14 ATS its last 19 home games and 3-8 ATS its last 11 after allowing fewer than 15 points its previous game. Take the points with the Giants.

The banged-up Giants are 2-2 on the season and have been a big dog twice along with a small favorite twice, but after an upset win at Buffalo, they are now a significant favorite? Not so fast. The young Giants secondary is still ailing and ranked dead last against the pass, allowing 316.3 yards per game. They would have allowed even more last week if run-oriented Buffalo hadn't negated several big passing plays with foolish penalties. The OVER is 4-1 when the Giants face the NFC, as well as 7-3 OVER on fieldturf. San Francisco is in town, fifth in the NFL in rushing. The 49ers are 7-2 ATS in their last nine games in October, as well as 3-0-1 ATS on fieldturf. Since the start of the 2013 season, the Niners are 7-0 ATS on the road vs. bad defensive teams (teams like New York that allow 5.7+ yards per play). And, under Tom Coughlin, the G-Men are 8-19 ATS at home after allowing 14 or fewer points last game. The Giants have two huge divisional games on deck against rivals Philadelphia and Dallas. This is a look-ahead spot for the home team in a game that will feature more offense and scoring than oddsmakers expect. Play San Francisco and the OVER.