New York Giants vs San Francisco 49ers Point Spread Picks

San Francisco has allowed an average of 25 points in its last four road games. In their previous two road contests, they lost to Houston (26-15) and Tampa Bay (30-19). Mac Jones (8 TDs, 5 INTs) has been filling in for QB Brock Purdy, who may be able to return this week. The defense ranks 22nd in yards allowed and 19th on third down (38.95%). The 49ers are 8-4 OVER the total in their last 12 road contests. New York's defense ranks 29th in yards allowed, 30th against the run, and 27th in points allowed (26.9 per game). They come home from a two-game road trip, scoring 52 points but losing both, allowing 33 and 38 points. Take San Francisco/New York OVER the total. 

New York got some much-needed momentum heading into this game by overcoming a 21-point third-quarter deficit and defeating Arizona 31-28 when Graham Gano kicked a 34-yard field goal with 19 seconds left. Daniel Jones redeemed himself after a disastrous Week 1 performance, completing 26 of 37 passes for 321 yards and two TDs for the Giants. Saquon Barkley (ankle) likely won't play against San Francisco, and the backups are Matt Breida and Gary Brightwell. The 49ers are 2-9 ATS their past 11 games in Week 3 and 4-9 ATS overall in Thursday games, including 1-6 ATS coming off a win. The Giants are 20-8 ATS as road underdogs of 3.5-10.5 points and they have covered eight of 11 overall on the road. Brock Purdy passed for 206 yards and ran for a TD, but the 49ers showed some vulnerability on defense as the Rams outgained them 386-365. Rookie wide receiver Puka Nacua had 15 catches for 147 yards to break the NFL's single-game receptions record for a rookie. The Niners are by far the superior team, but this is too many points. Take the points with the Giants as a Max Play.

San Francisco gets a break, not having to travel to the East Coast again for this game as it played on the same field last week in a 31-13 win over the Jets. The 49ers probably wish they were playing somewhere else, though, as they suffered numerous injuries on Sunday, attributing it to the turf. New York has some problems on offense as it has scored only 29 points its first two games, and the Giants lost Saquan Barkley for the season with a torn ACL. New York also placed wide receiver Sterling Shepard on injured reserve with a toe injury so their problems rival the Niners. Nick Mullens will likely start for San Francisco after Jimmy Garoppolo went down with an ankle injury. Mullens started eight games for San Francisco in 2018 and finished with a 90.8 QB rating while completing 64.2 percent of his passes. Mullens threw for 2,277 yards and 13 touchdowns that season. The posted total is relatively low and the Giants faced two good defenses their first two games. The OVER is 8-3-1 in the Niners' last 12 games vs. NFC teams and they are 8-3-1 OVER as favorites. The Giants are 11-5 OVER following a loss and the Giants have gone OVER six years in a row in Week 3. Play the 49ers on the moneyline and the OVER.

This is not exactly a marquee Monday Night matchup as the teams have the second-lowest combined winning percentage (.176) for an MNF game played in November or later in NFL history. San Francisco has one potential bright spot as Nick Mullens played well in his first career start, but that's not much for a 2-7 team that is laying points. The 49ers had lost their previous six games and they are #20 in the league in total yards of offense as they keep going through quarterbacks with Jimmy Garoppolo (torn ACL) and C.J. Beathard (concussion) both out. Eli Manning again will try to get his team a win after close losses to Atlanta and Washington. The Giants come off a bye week and have had plenty of time to prepare for this one. Manning was 30-of-47 for 316 yards with a touchdown and two interceptions against the Redskins, but the Giants need to get Saquon Barkley in the mix as he carried 13 times for only 38 yards. New York is 5-0 ATS its last five games after scoring fewer than 15 points its previous game and 7-2 ATS its last nine following an ATS loss. San Francisco is 5-14 ATS its last 19 home games and 3-8 ATS its last 11 after allowing fewer than 15 points its previous game. Take the points with the Giants.