Previous Matchups & Picks

September 28, 2025 1:00pm ET
@
New Orleans Saints
New Orleans Saints
#255
Buffalo Bills
Buffalo Bills
#256

Lines & Odds

+14.5 (-110)
ATS
-14.5 (-110)
+817
Moneyline
-1389
OVER 48.5 (-115)
Total
UNDER 48.5 (-110)

Saints vs. Bills Spread Picks

Get this week's Saints vs. Bills point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Saints vs. Bills.

Public Consensus

Who was the public on? 65% of the public bets were on Buffalo Bills on the -14.5 ATS. And, 60% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 32.9 to 16.2 with Buffalo winning on the moneyline and on the spread and the game going OVER the total.

Pro Picks

These Pro Picks were released to clients on September 28, 2025 at 9:46AM ET.
img PARLAY

Buffalo (NFL-256) MONEYLINE + Detroit (NFL-262) MONEYLINE

September 28, 2025
img1:00 PM Eastern

Combine the Bills (-1190) and the Lions (-525) into a 2-team parlay at -344 odds.

Final Score

1
2
3
4
F
New Orleans Saints
7
3
6
3
19
Buffalo Bills img
14
0
7
10
31

NFL Pro Pick Results

Here’s how my Pro Picks are performing.

NFLNFL All Picks last 24.4 years
Wins
Losses
Units
3,186
2,837
+183.64
NFLNFL Max Plays last 24.4 years
Wins
Losses
Units
1,315
1,117
+162.07
NFLNFL Pick Samples last 16.1 years
Wins
Losses
Units
260
171
+101.60
NFLNFL All Preseason Picks last 23.0 years
Wins
Losses
Units
477
409
+48.23
NFLNFL All Playoff Picks last 13.1 years
Wins
Losses
Units
227
177
+42.81
NFLNFL Between teams last 3.8 years
Wins
Losses
Units
4
0
+3.15
November 25, 2021 8:20pm ET
@
Buffalo Bills
Buffalo Bills
#109
New Orleans Saints
New Orleans Saints
#110

Lines & Odds

-7 (-110)
ATS
+7 (-115)
-276
Moneyline
+228
OVER 45 (-110)
Total
UNDER 45 (-110)

Public Consensus

Who was the public on? 60% of the public bets were on Buffalo Bills on the -7 ATS. And, 64% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 24.0 to 21.2 with Buffalo winning on the moneyline, New Orleans winning on the spread and the game going OVER the total.

Pro Picks

These Pro Picks were released to clients on November 23, 2022 at 9:36PM ET.
img NFL

Buffalo at New Orleans

November 25, 2021
img8:20 PM Eastern

Buffalo had an inexplicable loss to Jacksonville and then bounced back in a big way beating the New York Jets, 45-17 the following week, and now the Bills need to redeem themselves after losing at home, 41-15 to Indianapolis on Sunday. The Bills couldn't stop Jonathan Taylor, who scored five times and rumbled his way to 185 yards rushing. Josh Allen had a rough day, completing just 21 of 35 with 2 interceptions. Fortunately for Buffalo, it gets New Orleans this week, and the Saints have lost three in a row, including 40-29 at Philadelphia on Sunday. Trevor Siemian threw 3 TD passes, but he was picked off twice, and the Saints defense gave up 242 rushing yards. Buffalo had allowed only an average of 12.3 points per game in its three previous games, and it will have better luck defending the run against the Saints, who average 117.9 yards on the ground. The UNDER is 8-1 in Buffalo's past nine games following a loss, and the Bills have stayed UNDER five of seven after losing by at least 10 points at home. Also, New Orleans is 8-0-1 UNDER its past nine Thursday games. Take the Bills on the moneyline for a Max Play, and also play the UNDER for a Max Play.

Final Score

1
2
3
4
F
Buffalo Bills img
7
3
14
7
31
New Orleans Saints
0
0
0
6
6
November 12, 2017 1:00pm ET
@
New Orleans Saints
New Orleans Saints
#263
Buffalo Bills
Buffalo Bills
#264

Lines & Odds

-2 (-115)
ATS
+2 (-105)
-129
Moneyline
+109
OVER 48 (-115)
Total
UNDER 48 (-105)

Public Consensus

Who was the public on? 56% of the public bets were on Buffalo Bills on the +2 ATS. 64% of the public money was on Buffalo Bills to win on the moneyline. And, 50% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that New Orleans would win by a score of 25.1 to 21.8 with New Orleans winning on the moneyline and on the spread and the game going UNDER the total.

Pro Picks

These Pro Picks were released to clients on November 10, 2023 at 12:05PM ET.
img NFL

New Orleans at Buffalo

November 12, 2017
img1:00 PM Eastern

Buffalo suffered from Thursday Night Game Syndrome as it was plagued by poor tackling as the New York Jets racked up 194 rushing yards. The Bills looked tired and unprepared for the short week, but they still are 5-3 straight-up and 5-2-1 ATS this season. Tyrod Taylor was 29-of-40 for 285 yards with two touchdowns and no interceptions against the Jets despite being sacked seven times. Taylor has a 65.3 percent completion rate with 10 touchdowns and only two picks. New Orleans is on a current six-game winning streak, but this will be its toughest road test since since Week 3 at Carolina. The Saints' other two road wins were at Miami and at Green Bay, which was without Aaron Rodgers. Buffalo has gone OVER its last three games and the Bills are 14-3 OVER their last 17 home games. Also, the Bills are 14-6 OVER their last 20 games overall and 8-2 OVER after an ATS loss. New Orleans is 27-12 OVER after allowing fewer than 15 points its previous game. Buffalo will be more rested this week and play the Bills and the OVER.

Final Score

1
2
3
4
F
New Orleans Saints img
7
10
20
10
47
Buffalo Bills
3
0
0
7
10
October 27, 2013 1:00pm ET
@
Buffalo Bills
Buffalo Bills
#217
New Orleans Saints
New Orleans Saints
#218

Lines & Odds

+10 (-109)
ATS
-10 (-112)
+422
Moneyline
-527
OVER 48 (-109)
Total
UNDER 48 (-108)

Public Consensus

Who was the public on? 76% of the public bets were on New Orleans Saints on the -10 ATS. 71% of the public money was on New Orleans Saints to win on the moneyline. And, 84% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that New Orleans would win by a score of 27.4 to 21.8 with New Orleans winning on the moneyline, Buffalo winning on the spread and the game going OVER the total.

Pro Picks

img NFL

Buffalo at New Orleans

October 27, 2013
img1:00 PM Eastern

For the last several years, the New Orleans Saints have had the reputation of being a powerful offensive team, and they have been. They also had one of the worst defenses last year, allowing over 30 points per game. This is a changed team, however, one that has held five of six opponents to 18 points or less. Great offenses can score 30+ points. That is something this Saints team did eight times a year ago, and 12 times the season before that. But, they have done so just twice this season. While Buffalo has both scored and allowed 20 points in every game this season, five of their seven games would have fallen shy of this total. Since the arrival of Sean Payton in the Bayou, the Saints are 8-1 UNDER at home after scoring 25+ points in three straight games. The Saints are still drawing high totals, but their defense is better and the offense isn't scoring at the same rate this year. This one stays UNDER the total.

Final Score

1
2
3
4
F
Buffalo Bills
0
10
0
7
17
New Orleans Saints img
7
14
7
7
35
September 27, 2009 4:05pm ET
@
New Orleans Saints
New Orleans Saints
#421
Buffalo Bills
Buffalo Bills
#422

Lines & Odds

-5.5 (-105)
ATS
+5.5 (-110)
-245
Moneyline
+210
OVER 51.5 (-110)
Total
UNDER 51.5 (-110)

Public Consensus

Who was the public on? 68% of the public bets were on New Orleans Saints on the -5.5 ATS. 52% of the public money was on Buffalo Bills to win on the moneyline. And, 65% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that New Orleans would win by a score of 28.0 to 23.4 with New Orleans winning on the moneyline, Buffalo winning on the spread and the game going UNDER the total.

Pro Picks

img NFL

New Orleans at Buffalo

September 27, 2009
img4:05 PM Eastern

The Saints are off to a flying start at 2-0, scoring 93 points in the process. Fantasy football owners of Drew Brees are already making room on their mantle for their league's trophy. The Saints beat a hapless Detroit team and an Eagles team without a QB, so I'm not jumping on the bandwagon just yet. Even if I was ready to hop on board, there wouldn't be room for me as those enamored with high-octane offense and spotless win-loss records are filling up the bandwagon quickly. You know what that means? Get off! The Bills suffered a horrible loss to New England by one point in the opener, but to their credit they came back strong against Tampa Bay. This team is better than most people think and they are are never an easy out at home (just ask New England). Coach Dick Juaron has posted a 15-3 ATS mark at home in non-conference games. The Bills have also been a top home dog team with an 8-4 ATS mark. Drew Brees is getting all the headlines, but we have to note that Bills QB Trent Edwards finally has some weapons at his disposal, and last week hit Lee Evans for a 32-yard TD and Terrell Ownes for a 43-yarder. While the Bills secondary has given up a lot of yards, teams have been forced to the air because they have gotten leads in both games. The good news is that the Bills have had a pick-six in each of their first two games. The Saints' pass defense has been its usual futile self as they rank No. 29 against the pass. With the Bills piling up 438 yards of offense last week, they should be able to move the ball against the Saints. The public loves a scoring team and it has driven this line up to +6, with 76% backing the Saints on the road. That is just too many points for an improving Bills team that has proven to be very tough in this spot at home.

Final Score

1
2
3
4
F
New Orleans Saints img
7
3
0
17
27
Buffalo Bills
0
7
0
0
7

Get free NFL Picks

I pour over the data, injuries, news, and odds every morning. You get the best bets delivered to your inbox.