Pittsburgh at Louisville

Mismatches will abound in this one as Pitt is just weak this season, and there is no real way around that. Lousiville, although they tripped-up this season against S. Florida and W. Virginia, is clearly the most talented team in this conference and has the talent on offense to put up points in a hurry. Pitt's offense has been overmatched and they have been plagued by poor offensive line play, while the defense strongly resembles cheese of the swiss variety. Home favorites off a win by 10 points or more over a conference rival now facing an opponent off 3 straight wins against conference rivals are 45-15 ATS (75%) over the last 10 seasons. Louisville is 8-1 ATS the last two seasons off a road game, 13-5 ATS as a favorite, and 8-0 ATS at home over that same span. Two stars on the Cardinals of Louisville.