Michigan State at USC

Michigan State lost seven of its final nine games last season. They're 3-0 in 2025, but haven't been that impressive (0-3 ATS). They've beaten Western Michigan (23-6) and Youngstown (41-24), while needing double overtime to survive against Boston College (42-40), allowing 457 yards. All those games were at home, and now they fly to the West Coast. Michigan State is on a 7-17-1 ATS run. No. 25 USC's offense is scorching, No. 1 in the country, averaging 55 points and 604 yards. USC is on a 12-7 ATS run, and the visitors don't have the offense to keep pace. Play USC.