This Pro Pick was released to clients on October 15, 2026 at 1:00PM ET.
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Louisville at Syracuse

October 17, 2026
img7:30 PM Eastern

Louisville scored 44 on Florida State last Friday and gained 537 yards while allowing 362. It is 3-3, and it lost its three games by three points: 41-38 to Ole Miss, 30-27 to Wake Forest, and 31-28 at NC State. Louisville scores 39.5 points per game, 16th among the 138 FBS teams, and has scored 27 or more in every game this season. It gains 495 yards per game and has taken the ball away nine times while losing it four. It allows 27.7 points per game, tied for 103rd. Syracuse is 2-3, scores 32.8 points per game (53rd), and allows 24 points per game (tied for 74th). It allows 311 yards per game. It lost 28-25 at Virginia last Saturday, and it lost 21-18 to Cal and 27-13 at Pittsburgh before that. Its two wins were 66-3 over New Hampshire and 42-41 at UConn. Syracuse has lost the ball seven times in five games and taken it away six times, and Louisville ATS is the bet Saturday night. 

1.5 units on Louisville -14.5 (-110) (risk 1.5 to return 2.86)
Result:
LOSS
Final
1
2
3
4
F
Louisville Cardinals img
14
14
0
6
34
Syracuse Orange
10
13
0
3
26
consensus consensus
odds odds
 
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