This pick was released to clients on November 27, 2025 at 10:33AM ET.
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Kentucky at Louisville

November 29, 2025
img12:00 PM Eastern

It's not just the Governor's Cup that is on the line for Kentucky in this in-state rivalry match-up against Louisville. The 5-6 Wildcats need to win here to become Bowl eligible. That's a big deal for Kentucky. The Wildcats had put a late stretch hot streak to get into this position, beating Tennessee Tech, 42-10, upsetting Florida at home in smashing fashion, 38-7, and upsetting Auburn, 10-3, as an 11-point road underdog. But Kentucky's win streak was halted by Vanderbilt, 45-17, on the road last week. Now the Wildcats go from playing one of the better teams in the SEC to a middle-of-the-road ACC team. In other words, a step down. The Cardinals are in a late-season rut, losers of three in a row. They've scored only 51 combined points in these three games, all losses: SMU (38-6), Clemson (20-19), and California (29-26 in overtime), as an 18.5-point home favorite. The Cardinals are the more banged-up team, too, hit hard at the skill positions. Their top three running backs - Isaac Brown, Keyjuan Brown, and Duke Watson - are out, along with their top wide receiver, Chris Bell, who leads Louisville with 917 receiving yards and six touchdown catches. In addition, quarterback Miller Moss is questionable. Take Kentucky. 

1 unit on Kentucky +3 (-108) (risk 1 to return 1.93)
Result:
LOSS
Final
1
2
3
4
F
Kentucky Wildcats
0
0
0
0
0
Louisville Cardinals img
7
13
7
14
41
consensus consensus
odds odds
 
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