San Francisco 49ers vs Seattle Seahawks Point Spread Picks

San Francisco is 4-0 and scores 30.5 points per game, second in the league, and Seattle is 3-1, so this side needs a reason, and the reason is where the 49ers have played. Three of their four games were at home, and the other was the 27-7 win over the Rams in Australia, so this is their first game away from home in the United States. They've won by 20, 22, 6, and 10, with the 6 and 10 coming at home against Arizona and Denver. Seattle is 2-0 at home; its only loss was 33-31 at Washington, and I had the OVER when it beat the Chargers 30-23 last week. The Seahawks gain 5.9 yards per play and allow 4.0, with eight forced turnovers in four games, and San Francisco gains 6.8 and allows 4.8. Seattle is short at running back, with Zach Charbonnet out. San Francisco has Brandon Aiyuk out, four more receivers on injured reserve, Mike Evans questionable, and Nick Bosa doubtful. I’m taking Seattle at home Sunday afternoon.

Seattle beat the 49ers 13-3 on the road two weeks ago, although it seemed more dominating than the score indicates, as the Seahawks left a lot of points on the field. San Francisco was outgained 361-173, and Brock Purdy was held to 127 yards passing with an interception. Sam Darnold was 20 of 26 for 198 yards and no picks for the Seahawks. The 49ers are playing on a short week and coming off a road game after a tough 23-19 win at Philadelphia, while Seattle had the luxury of a week off. Seattle has gone OVER four straight divisional playoff games, and it is 7-1 OVER after allowing fewer than 250 total yards in its previous game. San Francisco is 10-2-1 OVER its past 13 road games against teams with winning home records. Seattle had its best rushing performance of the season (180 yards) in the last meeting, creating passing lanes for Darnold. Now the Seahawks just have to do a better job of finding the end zone, but I don't expect Kyle Shanahan's crew to go quietly. Take the Seahawks/Niners to go OVER. 

San Francisco has dominated this series, winning seven of the past eight meetings, including a 17-13 road win over Seattle in the opening week. The 49ers have overcome key defensive injuries to average 34.2 points per game in their last eight games. Christian McCaffrey is having a monster season, rushing for 1,179 yards and catching 96 passes for 890 yards while accounting for 17 touchdowns. Brock Purdy has the fourth-highest quarterback ranking in the league. These are players that can be trusted. Not so with Seattle quarterback Sam Darnold. This game decides the NFC West Division. Darnold does not have a good history in big games. He has been intercepted four times in his last four outings. Darnold has been picked off 14 times this season. That is the most in the NFC. Darnold could be missing his No. 2 wide receiver, Rashid Shaheed, who has a short week to clear concussion protocols after leaving Week 17’s game against the Panthers. Take the 49ers on the moneyline.

Seattle won six of its final eight games in 2024, but now has a new starting quarterback in Sam Darnold, who unexpectedly had a breakout season with the Vikings before signing with the Seahawks. Granted, he had a superstar receiver in Justin Jefferson, but he now has talented targets in Jaxon Smith-Njigba and Super Bowl MVP Cooper Kupp. Darnold threw for 4,319 yards and 35 TDs with just 12 interceptions last year. The defense returns 10 starters after finishing the season strong. Seattle has covered four of six as an underdog. San Francisco was a money burner, finishing 1-8 ATS in its last nine games and losing seven of eight outright. The 49ers are 0-5 ATS in their past five road games, 1-6 ATS overall against NFC teams. Seattle is 7-1 UNDER as a home underdog of 0.5-3.0 points. San Francisco is 9-2 UNDER its past 11 games in Week 1. Take the Seahawks and the UNDER.

San Francisco is ready to make another late run for its third straight win after defeating Dallas and Tampa Bay. The 49ers have covered four of five following an ATS loss, and Seattle has been 1-5 ATS in the past six meetings. The Seahawks have lost five of six with a 1-5 ATS record, including 26-20 in overtime to the Rams two weeks ago before their bye week. Seattle has gone UNDER three in a row, and Geno Smith threw three picks against the Rams, although he did have 363 passing yards and three TDs. San Francisco has won the past six meetings outright, and Seattle has lost seven of its past eight November games. Brock Purdy went 25-for-36 for 353 yards and two TDs with no interceptions against the Buccaneers, and the 49ers now have Christian McCaffrey back. San Francisco went UNDER for the third time in five games as the Bucs totaled only 215 yards of offense. Take the 49ers and the UNDER.