San Francisco 49ers at Tennessee Titans
Picks, Predictions & Odds

NFL Football Computer Pick with Spread, Moneyline & Total Odds

Below you will find San Francisco 49ers at Tennessee Titans picks, predictions and odds along with a matchup preview.
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Week 16: December 23, 2021 @ 8:20 PM ET

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Note: These are computer-derived picks and do NOT represent my official picks. In order to make final picks, there is much more analysis required (injuries, trends, situations and other technical analysis). If you want my full analysis, detailed write-ups, and official picks, be sure to get my email newsletter.


NFL Football Picks & Predictions Public Consensus

TEAM ATS TOTAL
BETS % BETS %
49ers 688 
52%
O 523 
54%
Titans 636 
48% 
U 451 
46% 

Wunderdog NFL Football Betting Picks & Predictions: Predicted Score

TEAM ODDS SCORE % CHANCE TO WIN
49ers -176 23.140
56%
Titans +154 20.960
44%

Wunderdog NFL Football Computer Predictions Against The Spread and Total

TEAM ATS TOTAL
49ers -3.5 45.0
Titans +3.5 45.0 U
FINAL SCORE
TEAM 1Q 2Q 3Q 4Q FINAL
49ers 7 3 0 7 17
Titans 0 0 10 10 20

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