Previous Matchups & Picks

January 11, 2026 4:30pm ET
@
San Francisco 49ers
San Francisco 49ers
#381
Philadelphia Eagles
Philadelphia Eagles
#382

Lines & Odds

+5.5 (-110)
ATS
-5.5 (-110)
+205
Moneyline
-250
OVER 44.5 (-110)
Total
UNDER 44.5 (-110)

49ers vs. Eagles Spread Picks

Get this week's 49ers vs. Eagles point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between 49ers vs. Eagles.

Public Consensus

Who was the public on? 58% of the public bets were on San Francisco 49ers on the +5.5 ATS. And, 52% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Philadelphia would win by a score of 24.1 to 20.3 with Philadelphia winning on the moneyline, San Francisco winning on the spread and the game going UNDER the total.

Pro Picks

This Pro Pick was released to clients on January 08, 2026 at 12:21PM ET.
img NFL

San Francisco at Philadelphia

January 11, 2026
img4:30 PM Eastern
Game of the Week

Philadelphia can take some lessons from the Seahawks on how to defend against the 49ers, who lost to Seattle 13-3 with a lot on the line last week. The game went UNDER by 32.5 points, and Brock Purdy was held to 127 yards passing with an interception. San Francisco totaled just 173 yards of offense. The Eagles have gone UNDER seven of nine, mostly winning with just enough offense and losing relatively low-scoring games in the second half of the season. The total has gone UNDER 14 of Philadelphia's past 18 January games, and they have stayed UNDER seven straight Wild Card games. The UNDER is 8-1 in San Francisco's past nine playoff road games. The Eagles are #5 in scoring defense, allowing 19.1 points per game, and the 49ers are #13, yielding 21.8. Take the UNDER. 

Final Score

1
2
3
4
F
San Francisco 49ers img
7
3
0
13
23
Philadelphia Eagles
6
7
3
3
19

NFL Pro Pick Results

Here’s how my Pro Picks are performing.

NFLNFL All Picks last 24.4 years
Wins
Losses
Units
3,186
2,837
+183.64
NFLNFL Max Plays last 24.4 years
Wins
Losses
Units
1,315
1,117
+162.07
NFLNFL Pick Samples last 16.1 years
Wins
Losses
Units
260
171
+101.60
NFLNFL All Preseason Picks last 23.0 years
Wins
Losses
Units
477
409
+48.23
NFLNFL All Playoff Picks last 13.1 years
Wins
Losses
Units
227
177
+42.81
NFLNFL Between teams last 1 day
Wins
Losses
Units
1
0
+1.77
December 3, 2023 4:25pm ET
@
San Francisco 49ers
San Francisco 49ers
#467
Philadelphia Eagles
Philadelphia Eagles
#468

Lines & Odds

-3 (-110)
ATS
+3 (-110)
-158
Moneyline
+128
OVER 47 (-110)
Total
UNDER 47 (-110)

Public Consensus

Who was the public on? 52% of the public bets were on Philadelphia Eagles on the +3 ATS. And, 60% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 25.4 to 22.8 with San Francisco winning on the moneyline, Philadelphia winning on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
San Francisco 49ers img
0
42
Philadelphia Eagles
6
19
January 29, 2023 3:00pm ET
@
San Francisco 49ers
San Francisco 49ers
#321
Philadelphia Eagles
Philadelphia Eagles
#322

Lines & Odds

+3 (-120)
ATS
-3 (+100)
+132
Moneyline
-153
OVER 44.5 (-110)
Total
UNDER 44.5 (-110)

Public Consensus

Who was the public on? 58% of the public bets were on Philadelphia Eagles on the -3 ATS. And, 59% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that Philadelphia would win by a score of 24.5 to 23.5 with Philadelphia winning on the moneyline, San Francisco winning on the spread and the game going OVER the total.

Pro Picks

These Pro Picks were released to clients on January 25, 2024 at 12:50PM ET.
img NFL

San Francisco at Philadelphia

January 29, 2023
img3:00 PM Eastern

San Francisco has won 12 games in a row with a 10-2 ATS record following its 19-12 victory over Dallas, and eight of those games went OVER. The Cowboys' inept offense prevented Sunday's game from going OVER and it didn't help that Dallas was playing its fourth consecutive road game. With Jalen Hurts under center, Philadelphia's offense will present a bigger challenge but the Niners have done well against potent passing attacks, going 10-2 ATS this season. Philly ranked 13th with a 65.4% completion percentage, and they were #3 with 7.6 yards per pass. Four of the Eagles' past seven wins have been against teams that finished under .500 and the other three were against the Giants, who barely showed last weekend. The Eagles are just 1-4 ATS their past five games and they are 3-8-1 ATS their past 12 after scoring at least 30 points in their previous game. Brock Purdy is 7-0 since replacing an injured Jimmy Garoppolo in Week 13, and he threw for 214 yards with no interceptions against Dallas as Elijah Mitchell and Christian McCaffrey teamed up for 86 rushing yards. The 49ers are 20-6 ATS in January, riding an 11-1 ATS streak since 2015. They are also 20-6 ATS in their past 26 games vs. the NFC, and 19-10 ATS when coming off a home win. Purdy has plenty of talent around him, including WR Brandon Aiyuk and tight end George Kittle, who made a sensational grab in a key moment of the game on Sunday. And don't forget Deebo Samuel. QB Hurts still is playing through a sprained shoulder and the Eagles racked up 268 yards on the ground against New York, but San Francisco finished #2 in rush defense this year and will force more passing by Hurts. At the end of the day, the Niners' D is the best in the NFL, allowing 16.4 PPG which is 3.1 fewer than the Eagles. They are also 20-10 ATS when getting points on the road since HC Kyle Shanahan took over. Philly has gone OVER 11 of 15 home games and eight of 10 overall following a win. Grab the points and if you have to pay a little extra juice to get this line up to +3, do it. Take the 49ers and the OVER.

Final Score

1
2
3
4
F
San Francisco 49ers
0
7
0
0
7
Philadelphia Eagles img
7
14
7
3
31
September 19, 2021 1:00pm ET
@
San Francisco 49ers
San Francisco 49ers
#281
Philadelphia Eagles
Philadelphia Eagles
#282

Lines & Odds

-3 (-105)
ATS
+3 (-120)
-146
Moneyline
+128
OVER 49 (-110)
Total
UNDER 49 (-110)

Public Consensus

Who was the public on? 53% of the public bets were on San Francisco 49ers on the -3 ATS. And, 54% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 25.8 to 23.7 with San Francisco winning on the moneyline, Philadelphia winning on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
San Francisco 49ers img
0
7
0
10
17
Philadelphia Eagles
3
0
0
8
11
October 4, 2020 8:20pm ET
@
Philadelphia Eagles
Philadelphia Eagles
#277
San Francisco 49ers
San Francisco 49ers
#278

Lines & Odds

+8 (-110)
ATS
-8 (-110)
+273
Moneyline
-348
OVER 46 (-110)
Total
UNDER 46 (-110)

Public Consensus

Who was the public on? 50% of the public bets were on Philadelphia Eagles on the +8 ATS. And, 59% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 26.4 to 18.8 with San Francisco winning on the moneyline, Philadelphia winning on the spread and the game going UNDER the total.

Pro Picks

This Pro Pick was released to clients on September 29, 2023 at 11:34AM ET.
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Philadelphia at San Francisco

October 4, 2020
img8:20 PM Eastern

Philadelphia can go ball-control with RB Miles Sanders and mobile QB Carson Wentz both averaging five or more yards per carry. The Eagles are #13 in the league in time of possession, plus 78-55 ATS away from home on natural grass. The defense is fifth in the NFL in total yards allowed, Top 10 against the run and the pass. They are a touchdown underdog to a San Francisco team that is home from a two-game road trip to the East Coast, at the Jets and Giants. They lost their only home game, 24-20 to Arizona, as a touchdown favorite. San Francisco has been without starting QB Jimmy Garoppolo with backup Nick Mullens running the offense. Garoppolo has a chance to play this weekend, recovering from a sprained ankle, while All-Pro tight end George Kittle missed the past two games with a sprained knee. The 49ers are 3-12 ATS versus teams that force 0.75 or fewer turnovers per game, so back the well-coached dog in a close one. Play Philadelphia.

Final Score

1
2
3
4
F
Philadelphia Eagles img
8
0
3
14
25
San Francisco 49ers
7
0
7
6
20

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