San Francisco at Seattle

San Francisco is 4-0 and scores 30.5 points per game, second in the league, and Seattle is 3-1, so this side needs a reason, and the reason is where the 49ers have played. Three of their four games were at home, and the other was the 27-7 win over the Rams in Australia, so this is their first game away from home in the United States. They've won by 20, 22, 6, and 10, with the 6 and 10 coming at home against Arizona and Denver. Seattle is 2-0 at home; its only loss was 33-31 at Washington, and I had the OVER when it beat the Chargers 30-23 last week. The Seahawks gain 5.9 yards per play and allow 4.0, with eight forced turnovers in four games, and San Francisco gains 6.8 and allows 4.8. Seattle is short at running back, with Zach Charbonnet out. San Francisco has Brandon Aiyuk out, four more receivers on injured reserve, Mike Evans questionable, and Nick Bosa doubtful. I’m taking Seattle at home Sunday afternoon.