Miami at San Francisco

San Francisco looked dominant in its opener, but the receiving corps that takes the field today is missing pieces from that win. Rookie receiver De'Zhaun Stribling is out, Ricky Pearsall is on injured reserve, and George Kittle is questionable, leaving the 49ers' passing game to rely on players well down the depth chart. Miami was outplayed by Las Vegas last week and turned the ball over twice, and there is no getting around how far apart these two teams looked in Week 1. But covering a number this size doesn't require Miami to play well. It requires San Francisco's offense to hit the same explosive output it managed a week ago without some of the players who got it there, and that is not a safe assumption for a double-digit number. Home favorites lose key weapons and still cover all the time, but rarely by the same margin they won by when everyone was healthy. Take Miami with the points.