Previous Matchups & Picks

September 14, 2025 1:00pm ET
@
San Francisco 49ers
San Francisco 49ers
#267
New Orleans Saints
New Orleans Saints
#268

Lines & Odds

-3 (-105)
ATS
+3 (-115)
-159
Moneyline
+136
OVER 40.5 (-110)
Total
UNDER 40.5 (-110)

49ers vs. Saints Spread Picks

Get this week's 49ers vs. Saints point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between 49ers vs. Saints.

Public Consensus

Who was the public on? 64% of the public bets were on San Francisco 49ers on the -3 ATS. And, 65% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 22.0 to 19.9 with San Francisco winning on the moneyline, New Orleans winning on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on September 12, 2025 at 9:49AM ET.
img NFL

San Francisco at New Orleans

September 14, 2025
img1:00 PM Eastern

The San Francisco 49ers ran off 71 plays last week, and they limited their opponent, the Seattle Seahawks, to 49 plays. They did this on the road vs. a good offensive team. The one certainty that comes with San Francisco is that it seems like every year, they are solid once again on defense. That spells trouble for a New Orleans team that has a minimal offense and was held to 13 points at home by Arizona. They stayed in the game with defense. The New Orleans offense did not have a turnover, which was another reason they remained in the game. These teams have had a tendency to play low-scoring games over the last 22 meetings, which shows a 14-7-1 mark to the under. Make the play UNDER the total.

Final Score

1
2
3
4
F
San Francisco 49ers img
6
10
3
7
26
New Orleans Saints
0
7
7
7
21

NFL Pro Pick Results

Here’s how my Pro Picks are performing.

NFLNFL All Picks last 24.4 years
Wins
Losses
Units
3,186
2,837
+183.64
NFLNFL Max Plays last 24.4 years
Wins
Losses
Units
1,315
1,117
+162.07
NFLNFL Pick Samples last 16.1 years
Wins
Losses
Units
260
171
+101.60
NFLNFL All Preseason Picks last 23.0 years
Wins
Losses
Units
477
409
+48.23
NFLNFL All Playoff Picks last 13.1 years
Wins
Losses
Units
227
177
+42.81
August 18, 2024 8:00pm ET
@
New Orleans Saints
New Orleans Saints
#429
San Francisco 49ers
San Francisco 49ers
#430

Lines & Odds

-1 (-115)
ATS
+1 (-105)
-113
Moneyline
-107
OVER 38 (-109)
Total
UNDER 38 (-112)

Computer Predictions

My computer prediction for this game was that New Orleans would win by a score of 19.5 to 18.5 with New Orleans winning on the moneyline.

Pro Picks

These Pro Picks were released to clients on August 15, 2024 at 10:53AM ET.
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New Orleans at San Francisco

August 18, 2024
img8:00 PM Eastern

It's the second straight preseason road game for New Orleans. The defense played well in Week 1, winning at Arizona. Coach Dennis Allen has won three of his last four preseason games, including 2-0 on the road winning at the Chargers (22-17) and at Arizona (16-14). San Francisco kept it vanilla on offense in the opener, a 17-13 loss to Tennessee. They were 4-of-13 on third and fourth down. After QB Brock Purdy, the backups are Joshua Dobbs, Brandon Allen, and Tanner Mordecai. Coach Kyle Shanahan has lost four of his last five preseason games showing nothing. The 49ers offense has averaged just 10.6 points in its last five preseason contests. Take New Orleans + UNDER the total. 

 

Final Score

1
2
3
4
F
New Orleans Saints
0
7
3
0
10
San Francisco 49ers img
0
13
0
3
16
November 27, 2022 4:25pm ET
@
New Orleans Saints
New Orleans Saints
#271
San Francisco 49ers
San Francisco 49ers
#272

Lines & Odds

+8.5 (-110)
ATS
-8.5 (-110)
+329
Moneyline
-429
OVER 43.5 (-110)
Total
UNDER 43.5 (-110)

Public Consensus

Who was the public on? 53% of the public bets were on San Francisco 49ers on the -8.5 ATS. And, 56% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 25.6 to 18.0 with San Francisco winning on the moneyline, New Orleans winning on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on November 24, 2023 at 10:54AM ET.
img NFL

New Orleans at San Francisco

November 27, 2022
img4:25 PM Eastern

New Orleans just hasn't been able to stay healthy. Two quarterbacks have combined for 18 TDs, 12 picks, and over the last three games, the offense has averaged 16.6 points. At least the defense has been improving a lot, allowing 16.75 points over the last four contests. They run into a San Francisco defense that is a powerhouse unit, one ranked first in the NFL in yards allowed and against the run, plus fourth in points surrendered (17.3 pg). The offense is ball-control, ranked seventh in time of possession, which chews up yards and the clock. And the 49ers are 14-4 UNDER the total against teams that force 0.75 or fewer turnovers per contest. Take New Orleans/San Francisco UNDER the total.

Final Score

1
2
3
4
F
New Orleans Saints
0
0
0
0
0
San Francisco 49ers img
3
7
3
0
13
November 15, 2020 4:25pm ET
@
San Francisco 49ers
San Francisco 49ers
#271
New Orleans Saints
New Orleans Saints
#272

Lines & Odds

+9 (-105)
ATS
-9 (-115)
+319
Moneyline
-414
OVER 49.5 (-110)
Total
UNDER 49.5 (-110)

Public Consensus

Who was the public on? 67% of the public bets were on New Orleans Saints on the -9 ATS. And, 62% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that New Orleans would win by a score of 28.2 to 22.2 with New Orleans winning on the moneyline, San Francisco winning on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
San Francisco 49ers
7
3
0
3
13
New Orleans Saints img
0
17
0
10
27
December 8, 2019 1:00pm ET
@
San Francisco 49ers
San Francisco 49ers
#137
New Orleans Saints
New Orleans Saints
#138

Lines & Odds

+1.5 (-115)
ATS
-1.5 (-105)
+101
Moneyline
-120
OVER 45 (-110)
Total
UNDER 45 (-110)

Public Consensus

Who was the public on? 52% of the public bets were on San Francisco 49ers on the +1.5 ATS. And, 61% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 23.0 to 21.2 with San Francisco winning on the moneyline and on the spread and the game going UNDER the total.

Final Score

1
2
3
4
F
San Francisco 49ers img
7
21
7
13
48
New Orleans Saints
13
14
6
13
46

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