This is a high total because of Tom Brady and the New England offense, but don't overlook the Patriots' defense that is sixth in the NFL in points allowed. New England has gone UNDER in five of six road games and they are a long way from home for this one. They face a dreadful San Francisco offense that is #29 in total yards, and #22 in points scored. San Francisco is 20-8 UNDER the total at home, including 17-7 UNDER after accumulating fewer than 90 yards rushing in their previous game. With rain expected, don't look for as much offense as the oddsmakers and the public expect. Play this one to finish UNDER.
Previous Matchups & Picks
September 29, 2024 4:05pm ET
@
New England Patriots
#281
San Francisco 49ers
#282
Lines & Odds
+10.5 (-110)
ATS
-10.5 (-110)
+455
Moneyline
-618
OVER 42 (-110)
Total
UNDER 42 (-110)
Patriots vs. 49ers Spread Picks
Get this week's Patriots vs. 49ers point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Patriots vs. 49ers.
Public Consensus
Who was the public on? 55% of the public bets were on San Francisco 49ers on the -10.5 ATS. And, 58% of the bets were on the game to go UNDER the total.
Computer Predictions
My computer prediction for this game was that San Francisco would win by a score of 24.0 to 16.5 with San Francisco winning on the moneyline, New England winning on the spread and the game going UNDER the total.
Final Score
1
2
3
4
F
New England Patriots
0
3
7
3
13
San Francisco 49ers 
6
14
7
3
30
NFL Pro Pick Results
Here’s how my Pro Picks are performing.
NFLNFL
All Picks last 24.4 years
Wins
Losses
Units
3,186
2,837
+183.64
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Max Plays last 24.4 years
Wins
Losses
Units
1,315
1,117
+162.07
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Pick Samples last 16.1 years
Wins
Losses
Units
260
171
+101.60
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All Preseason Picks last 23.0 years
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Losses
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477
409
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177
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Between teams last 1 day
Wins
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Units
1
0
+0.95
October 25, 2020 4:25pm ET
@
San Francisco 49ers
#469
New England Patriots
#470
Lines & Odds
+3 (-115)
ATS
-3 (-120)
+142
Moneyline
-165
OVER 44.5 (-110)
Total
UNDER 44.5 (-110)
Public Consensus
Who was the public on? 57% of the public bets were on San Francisco 49ers on the +3 ATS. And, 56% of the bets were on the game to go UNDER the total.
Computer Predictions
My computer prediction for this game was that New England would win by a score of 22.3 to 21.7 with New England winning on the moneyline, San Francisco winning on the spread and the game going UNDER the total.
Final Score
1
2
3
4
F
San Francisco 49ers
7
16
7
3
33
New England Patriots
0
3
3
0
6
November 20, 2016 4:25pm ET
@
New England Patriots
#469
San Francisco 49ers
#470
Lines & Odds
-12 (+105)
ATS
Moneyline
OVER 51.5 (-110)
Total
Public Consensus
Who was the public on? 77% of the public bets were on New England Patriots on the -12 ATS. 69% of the public money was on New England Patriots to win on the moneyline. And, 59% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that New England would win by a score of 30.5 to 19.4 with New England winning on the moneyline, San Francisco winning on the spread and the game going UNDER the total.
Pro Picks
This Pro Pick was released to clients on November 17, 2023 at 10:45AM ET.
NFL
New England at San Francisco
November 20, 2016
4:25 PM Eastern
Final Score
1
2
3
4
F
New England Patriots
6
7
0
17
30
San Francisco 49ers
3
7
0
7
17
December 16, 2012 8:20pm ET
@
San Francisco 49ers
#329
New England Patriots
#330
Lines & Odds
+4 (-109)
ATS
-4 (-110)
+181
Moneyline
-213
OVER 47.5 (-109)
Total
UNDER 47.5 (-110)
Public Consensus
Who was the public on? 68% of the public bets were on New England Patriots on the -4 ATS. 66% of the public money was on New England Patriots to win on the moneyline. And, 71% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that New England would win by a score of 24.8 to 22.6 with New England winning on the moneyline, San Francisco winning on the spread and the game going UNDER the total.
Final Score
1
2
3
4
F
San Francisco 49ers
7
10
14
10
41
New England Patriots
0
3
7
24
34
October 5, 2008 4:15pm ET
@
New England Patriots
#423
San Francisco 49ers
#424
Lines & Odds
-3 (-118)
ATS
+3 (-101)
-168
Moneyline
+149
OVER 41 (-109)
Total
UNDER 41 (-109)
Computer Predictions
My computer prediction for this game was that New England would win by a score of 22.8 to 18.0 with New England winning on the moneyline and on the spread and the game going UNDER the total.
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