Kansas City Chiefs vs Los Angeles Chargers Point Spread Picks

Combine the Chiefs (-260) and the Demon Deacons (-3000) into a 2-team parlay at -224 odds.

Kansas City has won the past seven meetings, and the last three have been easy UNDERS, including their wins last season, 17-10 and 19-17. The Chiefs have won 11 of 14 road games overall and 10 straight on the road when playing the Chargers. Kansas City has gone UNDER six of eight against AFC opponents. Los Angeles has lost six of nine September games, and it is 2-8-1 ATS in its past 11 as an underdog. The Chargers are 1-5 ATS in their past six as underdogs of 0.5-3.0. The Chiefs suffered key injuries to the wide receiver corps, but should be healthier this year, and the offensive line must also improve. If both of those concerns are corrected, Patrick Mahomes will have another banner season after a relatively disappointing 2024, at least for him. There are still some doubts about Justin Herbert, who was picked off four times in the Chargers' 32-12 loss to Houston in the playoffs. However, Herbert does hold the record for most passing yards in a quarterback's first five seasons. He'll have to continue that pace as his team lost several key players on the defensive side. Kansas City has gone UNDER four straight against the AFC West. This game is in São Paulo, Brazil. Take the Chiefs and the UNDER.

It's a low total, but two great quarterbacks face each other. Los Angeles QB Justin Herbert (13 TDs, one interception) has led the Chargers to wins in six of their last eight. Kansas City QB Patrick Mahomes (19 TDs, 11 INTs) leads an offense that is No. 1 in the NFL on third down (51.83%). When these teams met on this field a year ago, the Chiefs won 31-17, as Mahomes threw for 424 yards. Play Los Angeles/Kansas City OVER the total. 

Kansas City quarterback Patrick Mahomes won't play, but 34-year-old backup QB Blaine Gabbert is a veteran with 51 NFL TD passes. And this Kansas City defense is second in the NFL in yards allowed, third in points given up (17.6 per game), and Top 10 on third down (37.04%). The Chiefs are 41-21 ATS on the road against defenses that allow 24+ points per game. The Los Angeles defense has allowed the fourth-most yards and is ranked 17th on third down (38.43%). QB Justin Herbert is done for the season so QB Easton Stick gets another start. He has no TD passes in the last two games. The Chargers are 10-22 ATS at home after three straight defeats, 42-67 ATS at home after failing to cover, and 22-41 ATS at home versus winning teams in the second half of the season. Play Kansas City.