Previous Matchups & Picks

September 28, 2025 4:05pm ET
@
Jacksonville Jaguars
Jacksonville Jaguars
#267
San Francisco 49ers
San Francisco 49ers
#268

Lines & Odds

+3 (-110)
ATS
-3 (-110)
+143
Moneyline
-167
OVER 46 (-110)
Total
UNDER 46 (-110)

Jaguars vs. 49ers Spread Picks

Get this week's Jaguars vs. 49ers point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Jaguars vs. 49ers.

Public Consensus

Who was the public on? 60% of the public bets were on San Francisco 49ers on the -3 ATS. And, 68% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 24.8 to 20.4 with San Francisco winning on the moneyline and on the spread and the game going UNDER the total.

Final Score

1
2
3
4
F
Jacksonville Jaguars img
0
17
9
0
26
San Francisco 49ers
3
3
8
7
21

NFL Pro Pick Results

Here’s how my Pro Picks are performing.

NFLNFL All Picks last 24.4 years
Wins
Losses
Units
3,186
2,837
+183.64
NFLNFL Max Plays last 24.4 years
Wins
Losses
Units
1,315
1,117
+162.07
NFLNFL Pick Samples last 16.1 years
Wins
Losses
Units
260
171
+101.60
NFLNFL All Preseason Picks last 23.0 years
Wins
Losses
Units
477
409
+48.23
NFLNFL All Playoff Picks last 13.1 years
Wins
Losses
Units
227
177
+42.81
November 12, 2023 1:00pm ET
@
San Francisco 49ers
San Francisco 49ers
#247
Jacksonville Jaguars
Jacksonville Jaguars
#248

Lines & Odds

-3 (-120)
ATS
+3 (+100)
-171
Moneyline
+145
OVER 44.5 (-110)
Total
UNDER 44.5 (-110)

Public Consensus

Who was the public on? 55% of the public bets were on San Francisco 49ers on the -3 ATS. And, 53% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 23.2 to 22.0 with San Francisco winning on the moneyline, Jacksonville winning on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
San Francisco 49ers img
10
3
14
7
34
Jacksonville Jaguars
0
3
0
0
3
November 21, 2021 1:00pm ET
@
San Francisco 49ers
San Francisco 49ers
#453
Jacksonville Jaguars
Jacksonville Jaguars
#454

Lines & Odds

-6.5 (-110)
ATS
+6.5 (-110)
-268
Moneyline
+225
OVER 45.5 (-110)
Total
UNDER 45.5 (-110)

Public Consensus

Who was the public on? 64% of the public bets were on San Francisco 49ers on the -6.5 ATS. And, 64% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 26.2 to 19.3 with San Francisco winning on the moneyline and on the spread.

Final Score

1
2
3
4
F
San Francisco 49ers img
3
17
7
3
30
Jacksonville Jaguars
0
3
0
7
10
December 24, 2017 4:05pm ET
@
Jacksonville Jaguars
Jacksonville Jaguars
#123
San Francisco 49ers
San Francisco 49ers
#124

Lines & Odds

-4 (-111)
ATS
+4 (-109)
-214
Moneyline
+181
OVER 43 (-110)
Total
UNDER 43 (-110)

Public Consensus

Who was the public on? 51% of the public bets were on San Francisco 49ers on the +4 ATS.

Computer Predictions

My computer prediction for this game was that Jacksonville would win by a score of 24.3 to 17.7 with Jacksonville winning on the moneyline and on the spread and the game going UNDER the total.

Final Score

1
2
3
4
F
Jacksonville Jaguars
0
16
3
14
33
San Francisco 49ers img
10
6
7
21
44
October 27, 2013 1:00pm ET
vs.
San Francisco 49ers
San Francisco 49ers
#209
Jacksonville Jaguars
Jacksonville Jaguars
#210

Lines & Odds

-16 (-107)
ATS
+16 (-110)
-1334
Moneyline
+894
OVER 40 (-109)
Total
UNDER 40 (-109)

Public Consensus

Who was the public on? 76% of the public bets were on San Francisco 49ers on the -16 ATS. 64% of the public money was on San Francisco 49ers to win on the moneyline. And, 87% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 26.5 to 15.3 with San Francisco winning on the moneyline, Jacksonville winning on the spread and the game going OVER the total.

Pro Picks

img NFL

San Francisco vs. Jacksonville

October 27, 2013
img1:00 PM Eastern

The Jacksonville Jaguars won just two games a year ago, and it looks like they will be in a similar spot come season's end this year. The Jags have not won a game yet this season at 0-7, and now have to play one of the top teams in the league in the San Francisco 49ers. The big dog number has certainly not deterred bettors from betting the Niners, as they are lined up at 70% on the Niners. The problem is that they are on the wrong side of what history has shown. NFL teams that are winless through 7+ games are 47-21-4 ATS, covering over 69% of the time blind! Those numbers move to 12-1 ATS if the point spread is more than 11. This looks like an ugly play on a winless team, but history backs us up on this one. Take the points and play on Jacksonville.

Final Score

1
2
3
4
F
San Francisco 49ers img
14
14
7
7
42
Jacksonville Jaguars
0
3
7
0
10

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