Previous Matchups & Picks

September 28, 2025 4:05pm ET
@
Indianapolis Colts
Indianapolis Colts
#269
Los Angeles Rams
Los Angeles Rams
#270

Lines & Odds

+3.5 (-115)
ATS
-3.5 (-105)
+161
Moneyline
-187
OVER 49.5 (-110)
Total
UNDER 49.5 (-110)

Colts vs. Rams Spread Picks

Get this week's Colts vs. Rams point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Colts vs. Rams.

Public Consensus

Who was the public on? 56% of the public bets were on Los Angeles Rams on the -3.5 ATS. And, 55% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Los Angeles would win by a score of 25.4 to 23.7 with Los Angeles winning on the moneyline, Indianapolis winning on the spread and the game going UNDER the total.

Pro Picks

These Pro Picks were released to clients on September 26, 2025 at 1:38PM ET.
img NFL

Indianapolis at Los Angeles

September 28, 2025
img4:05 PM Eastern

Indianapolis is 3-0 and off to its best start since 2009, and the Colts are 5-0 ATS in their past five September games. Los Angeles is 1-6 ATS in its past seven Week 4 games. The Colts come off a 41-20 victory over Tennessee with Jonathan Taylor rushing for 102 yards and three TDs. Cornerback Kenny Moore returned an interception 32 yards for a TD on the game's third offensive play, and the Colts easily went OVER for the second game in a row and seventh in eight games dating to last season. Indianapolis is 5-0 OVER its past five road contests. The Rams are 5-1 OVER their past six September games and 6-1 OVER against teams with winning records. Daniel Jones continues to impress, finishing 18 of 25 for 228 yards and a touchdown against the Titans. The Rams might need more than a week to recover from an unbelievable 33-26 loss at Philadelphia. They first blew a 26-7 lead and then lost the win and cover on a blocked kick that was returned for a touchdown by 336-pounder Jordan Davis. The game soared OVER by 13.5 points. The Colts are averaging 34.3 points this season. Indianapolis has a solid secondary with 13 pass deflections and four picks this season. Take the Colts and the OVER.

Final Score

1
2
3
4
F
Indianapolis Colts
3
7
0
10
20
Los Angeles Rams img
3
10
0
14
27

NFL Pro Pick Results

Here’s how my Pro Picks are performing.

NFLNFL All Picks last 24.4 years
Wins
Losses
Units
3,186
2,837
+183.64
NFLNFL Max Plays last 24.4 years
Wins
Losses
Units
1,315
1,117
+162.07
NFLNFL Pick Samples last 16.1 years
Wins
Losses
Units
260
171
+101.60
NFLNFL All Preseason Picks last 23.0 years
Wins
Losses
Units
477
409
+48.23
NFLNFL All Playoff Picks last 13.1 years
Wins
Losses
Units
227
177
+42.81
October 1, 2023 1:02pm ET
@
Los Angeles Rams
Los Angeles Rams
#263
Indianapolis Colts
Indianapolis Colts
#264

Lines & Odds

-1.5 (-110)
ATS
+1.5 (-110)
-121
Moneyline
+101
OVER 44.5 (-110)
Total
UNDER 44.5 (-110)

Public Consensus

Who was the public on? 62% of the public bets were on Los Angeles Rams on the -1.5 ATS. And, 51% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that Los Angeles would win by a score of 23.7 to 21.6 with Los Angeles winning on the moneyline and on the spread and the game going OVER the total.

Final Score

1
2
3
4
O
F
Los Angeles Rams img
14
6
3
0
6
29
Indianapolis Colts
0
0
8
15
0
23
September 19, 2021 1:00pm ET
@
Los Angeles Rams
Los Angeles Rams
#279
Indianapolis Colts
Indianapolis Colts
#280

Lines & Odds

-4 (-110)
ATS
+4 (-110)
-203
Moneyline
+175
OVER 47.5 (-110)
Total
UNDER 47.5 (-110)

Public Consensus

Who was the public on? 78% of the public bets were on Los Angeles Rams on the -4 ATS. And, 56% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Los Angeles would win by a score of 24.5 to 22.3 with Los Angeles winning on the moneyline, Indianapolis winning on the spread and the game going UNDER the total.

Pro Picks

This Pro Pick was released to clients on September 15, 2023 at 11:17AM ET.
img NFL

Los Angeles at Indianapolis

September 19, 2021
img1:00 PM Eastern

This is the first road game for Los Angeles. The Rams got a 20-point win with new QB Matthew Stafford, though the final was a little misleading. It was 20-14 in the third quarter, and the new-look offense was stagnant at times, rushing for just 74 yards (3.2 yards per carry). The Rams were a .500 road team last season, losing three of their first five away from home. Indianapolis has plenty of depth, balance, and talent and is coming off of an 11-5 season. They were out of sync in Week 1 last year, too, losing at Jacksonville before winning three straight at home by scores of 28-11, 36-7, and 31-27. New QB Carson Wentz threw for 251 yards against Seattle while the ground game had 113 yards. Plus, NFL dogs that averaged 275+ yards passing the previous season are 29-5 ATS after a game where they allowed 7 or more passing yards per attempt. Play Indianapolis.

Final Score

1
2
3
4
F
Los Angeles Rams img
7
3
7
10
27
Indianapolis Colts
0
6
8
10
24
September 10, 2017 4:05pm ET
@
Indianapolis Colts
Indianapolis Colts
#471
Los Angeles Rams
Los Angeles Rams
#472

Lines & Odds

+3.5 (-110)
ATS
-3.5 (-110)
+162
Moneyline
-187
OVER 41.5 (-110)
Total
UNDER 41.5 (-110)

Public Consensus

Who was the public on? 71% of the public bets were on Los Angeles Rams on the -3.5 ATS. 59% of the public money was on Los Angeles Rams to win on the moneyline. And, 50% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that Indianapolis would win by a score of 22.9 to 18.9 with Indianapolis winning on the moneyline and on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
Indianapolis Colts
3
0
0
6
9
Los Angeles Rams img
10
17
10
9
46

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