Previous Matchups & Picks

December 1, 2024 8:20pm ET
@
San Francisco 49ers
San Francisco 49ers
#481
Buffalo Bills
Buffalo Bills
#482

Lines & Odds

+6.5 (-110)
ATS
-6.5 (-110)
+253
Moneyline
-314
OVER 45 (-110)
Total
UNDER 45 (-110)

49ers vs. Bills Spread Picks

Get this week's 49ers vs. Bills point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between 49ers vs. Bills.

Public Consensus

Who was the public on? 69% of the public bets were on Buffalo Bills on the -6.5 ATS. And, 56% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 27.3 to 19.4 with Buffalo winning on the moneyline and on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on December 01, 2024 at 12:11PM ET.
img PARLAY

New York (NBA-540) MONEYLINE + Buffalo (NFL-482) MONEYLINE

December 1, 2024
img6:00 PM Eastern

Combine the Knicks (-700) and the Bills (-280) into a 2-team parlay at -181 odds.

Final Score

1
2
3
4
F
San Francisco 49ers
3
0
7
0
10
Buffalo Bills img
7
14
7
7
35

NFL Pro Pick Results

Here’s how my Pro Picks are performing.

NFLNFL All Picks last 25.0 years
Wins
Losses
Units
3,208
2,857
+182.36
NFLNFL Max Plays last 25.0 years
Wins
Losses
Units
1,320
1,125
+155.43
NFLNFL Free Picks last 16.6 years
Wins
Losses
Units
261
173
+99.53
NFLNFL All Preseason Picks last 24.0 years
Wins
Losses
Units
499
429
+46.95
NFLNFL All Playoff Picks last 13.1 years
Wins
Losses
Units
227
177
+42.81
NFLNFL Between teams last 16.0 years
Wins
Losses
Units
3
1
+4.01
December 7, 2020 8:15pm ET
vs.
Buffalo Bills
Buffalo Bills
#485
San Francisco 49ers
San Francisco 49ers
#486

Lines & Odds

+1.5 (-120)
ATS
-1.5 (-110)
+109
Moneyline
-130
OVER 48 (-110)
Total
UNDER 48 (-110)

Public Consensus

Who was the public on? 54% of the public bets were on Buffalo Bills on the +1.5 ATS. And, 59% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 24.9 to 24.1 with Buffalo winning on the moneyline and on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
Buffalo Bills img
0
17
10
7
34
San Francisco 49ers
7
0
10
7
24
October 16, 2016 1:00pm ET
@
San Francisco 49ers
San Francisco 49ers
#261
Buffalo Bills
Buffalo Bills
#262

Lines & Odds

+7.5 (-110)
ATS
-7.5 (-105)
+295
Moneyline
-310
OVER 43.5 (-110)
Total

Public Consensus

Who was the public on? 53% of the public bets were on Buffalo Bills on the -7.5 ATS. 56% of the public money was on San Francisco 49ers to win on the moneyline. And, 56% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 26.2 to 17.8 with Buffalo winning on the moneyline and on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
San Francisco 49ers
3
10
0
3
16
Buffalo Bills img
7
10
7
21
45
October 7, 2012 4:25pm ET
@
Buffalo Bills
Buffalo Bills
#431
San Francisco 49ers
San Francisco 49ers
#432

Lines & Odds

+10 (-105)
ATS
-10 (-110)
+350
Moneyline
-430
OVER 45.5 (-110)
Total
UNDER 45.5 (-110)

Public Consensus

Who was the public on? 73% of the public bets were on San Francisco 49ers on the -10 ATS. 77% of the public money was on San Francisco 49ers to win on the moneyline. And, 51% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 27.6 to 17.8 with San Francisco winning on the moneyline, Buffalo winning on the spread and the game going UNDER the total.

Pro Picks

img NFL

Buffalo at San Francisco

October 7, 2012
img4:25 PM Eastern

The San Francisco 49ers re-asserted their air of invincibility last week with a 34-0 whitewashing of the Jets. The Niners took out their frustrations from a loss in Minnesota. After a 34-0 win and the Minnesota monkey off their back, will San Francisco be crisp for another AFC opponent? Don't forget that San Francisco has a date and a score to settle with the Giants next week. Buffalo has looked both good and bad this season, as the offense has been their calling card. The offense has averaged close to 30 points per game, and they had New England on the ropes last week up 21-7 before they imploded. The Niners aren't the blowout type of team - they wear teams out with patience and a solid defense. Their last seven wins show just last week's win vs. the Jets the only blowout. All the others were by 8 points or less. The Niners are just 8-24-4 ATS following a win of 14 points or more. San Francisco has unfinished business to attend to next week, and have gotten satisfaction last week after their first loss. Play on Buffalo.

Final Score

1
2
3
4
F
Buffalo Bills
0
3
0
0
3
San Francisco 49ers img
3
14
7
21
45
November 30, 2008 1:00pm ET
@
San Francisco 49ers
San Francisco 49ers
#391
Buffalo Bills
Buffalo Bills
#392

Lines & Odds

+6.5 (-110)
ATS
-6.5 (-101)
+235
Moneyline
-272
OVER 43 (-108)
Total
UNDER 43 (-109)

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 25.4 to 20.1 with Buffalo winning on the moneyline, San Francisco winning on the spread and the game going OVER the total.

Pro Picks

img NFL

San Francisco at Buffalo

November 30, 2008
img1:00 PM Eastern

I think by now everyone saw the meltdown by Mike Singletary after his first game taking over this team. The fact is his team was playing heartless and soft, and he called some players out, and the Niners are now playing hard for him. Buffalo is off of a big win in Kansas City, at least in the eyes of the public. But how quickly people forget. This is a team that dropped four straight before their win in Kansas City last week. What they did last week was beat a team that has been 1-19 in their last 20 regular season games, so using that game as a marker for a team to have turned things around would be a big mistake. They gave up 31 points to a team that only surpassed that mark in a game against Denver, one of the worst defensive teams in the league. The win doesn't make up for the fact that this once 5-1 team that was allowing 19.6 ppg, has now gone 1-4 allowing 26.2 ppg. They have defensive issues, and have only gotten to the QB 18 times all season. Just remember Oakland got 23 on this team, Kansas City just got 31, and Cleveland posted 29. The Niners have hung tough on the road at Arizona, who has been blowing everyone out at home. They crushed St. Louis on the road, and matched Dallas first down for first down, with 16 apiece. Buffalo should not be a hefty chalk here, and I'll back the Niners with the points.

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