Previous Matchups & Picks

January 11, 2026 1:00pm ET
@
Buffalo Bills
Buffalo Bills
#379
Jacksonville Jaguars
Jacksonville Jaguars
#380

Lines & Odds

+1.5 (-110)
ATS
-1.5 (-110)
+102
Moneyline
-122
OVER 51 (-110)
Total
UNDER 51 (-110)

Bills vs. Jaguars Spread Picks

Get this week's Bills vs. Jaguars point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Bills vs. Jaguars.

Public Consensus

Who was the public on? 57% of the public bets were on Jacksonville Jaguars on the -1.5 ATS. And, 65% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Jacksonville would win by a score of 26.5 to 24.4 with Jacksonville winning on the moneyline and on the spread and the game going UNDER the total.

Pro Picks

These Pro Picks were released to clients on January 08, 2026 at 12:21PM ET.
img NFL

Buffalo at Jacksonville

January 11, 2026
img1:00 PM Eastern

Buffalo won five of its last six games, and the lone loss was by one point to Philadelphia. The Bills averaged 31.6 points in the five victories, and they outgained the Jets 470-122 with Josh Allen watching from the sidelines. Mitchell Trubisky completed 22 of 29 for 259 yards and four TDs against the hapless Jets. Buffalo has won four of six road games and five straight against AFC opponents. Jacksonville is 6-14 straight up in its past 20 games as an underdog. The Jaguars got a win at Denver, but otherwise, they have mostly taken advantage of a soft schedule, although Liam Coen deserves to be a Coach of the Year candidate for the job he has done with Trevor Lawrence. Jacksonville is 4-0 UNDER in its past four home games against teams with winning road records. Buffalo's defense is peaking at the right time as the Bills have allowed just 13.7 points per game in their past three games. The Bills' great offensive linemen can hold their own against the Jacksonville defense, and obviously, they, along with Josh Allen, have been battle-tested in the postseason. Take the Bills on the moneyline and the UNDER. 

Final Score

1
2
3
4
F
Buffalo Bills img
3
7
3
14
27
Jacksonville Jaguars
0
7
3
14
24

NFL Pro Pick Results

Here’s how my Pro Picks are performing.

NFLNFL All Picks last 25.0 years
Wins
Losses
Units
3,208
2,857
+182.36
NFLNFL Max Plays last 25.0 years
Wins
Losses
Units
1,320
1,125
+155.43
NFLNFL Free Picks last 16.6 years
Wins
Losses
Units
261
173
+99.53
NFLNFL All Preseason Picks last 24.0 years
Wins
Losses
Units
499
429
+46.95
NFLNFL All Playoff Picks last 13.1 years
Wins
Losses
Units
227
177
+42.81
NFLNFL Between teams last 4.2 years
Wins
Losses
Units
4
0
+5.57
September 23, 2024 7:30pm ET
@
Jacksonville Jaguars
Jacksonville Jaguars
#477
Buffalo Bills
Buffalo Bills
#478

Lines & Odds

+4 (-110)
ATS
-4 (-110)
+186
Moneyline
-224
OVER 46.5 (-115)
Total
UNDER 46.5 (-105)

Public Consensus

Who was the public on? 60% of the public bets were on Buffalo Bills on the -4 ATS. And, 52% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 26.5 to 18.6 with Buffalo winning on the moneyline and on the spread and the game going UNDER the total.

Final Score

1
2
3
4
F
Jacksonville Jaguars
0
3
7
0
10
Buffalo Bills img
13
21
3
10
47
October 8, 2023 9:30am ET
vs.
Jacksonville Jaguars
Jacksonville Jaguars
#451
Buffalo Bills
Buffalo Bills
#452

Lines & Odds

+5 (-110)
ATS
-5 (-110)
+199
Moneyline
-243
OVER 48.5 (-110)
Total
UNDER 48.5 (-110)

Public Consensus

Who was the public on? 68% of the public bets were on Buffalo Bills on the -5 ATS. And, 62% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 27.0 to 21.5 with Buffalo winning on the moneyline and on the spread.

Pro Picks

This Pro Pick was released to clients on October 06, 2023 at 12:32PM ET.
img NFL

Jacksonville vs. Buffalo

October 8, 2023
img9:30 AM Eastern

This will be Jacksonville's second consecutive game in London after defeating Atlanta 23-7 in Week 4 and bouncing back from a poor performance the week before when the Jaguars lost 37-17 to Houston. Trevor Lawrence threw for 207 yards on 23 of 30 with no interceptions and Darious Williams returned an interception 61 yards for a score for the Jaguars, who beat the Bills 9-6 in the last meeting in 2021. Jacksonville is 8-3 ATS its past 11 games, 6-0-1 ATS against teams with winning records and 3-0-1 ATS as an underdog of 3.5-10.0 points. Buffalo is just 1-4 ATS its past five games after totaling more than 350 yards its previous game and they are in letdown mode after their big game against Miami. Also, the Bills are 1-5 ATS their past six as favorites of more than three points versus a team coming off a double-digit win. Buffalo cornerback Tre'Davious White suffered an Achilles injury and is out for the year. The Dolphins did accumulate 393 yards of offense against the Bills on Sunday, but were stymied by lack of execution on third and fourth down conversions. Jacksonville has covered six of eight following a win and five of six as an underdog. Take the Jaguars.

Final Score

1
2
3
4
F
Jacksonville Jaguars img
11
0
0
14
25
Buffalo Bills
0
7
0
13
20
November 7, 2021 1:00pm ET
@
Buffalo Bills
Buffalo Bills
#459
Jacksonville Jaguars
Jacksonville Jaguars
#460

Lines & Odds

-16 (-110)
ATS
+16 (-110)
-1154
Moneyline
+761
OVER 48.5 (-110)
Total
UNDER 48.5 (-110)

Public Consensus

Who was the public on? 68% of the public bets were on Buffalo Bills on the -16 ATS. And, 56% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 31.0 to 17.3 with Buffalo winning on the moneyline, Jacksonville winning on the spread and the game going UNDER the total.

Pro Picks

This Pro Pick was released to clients on November 03, 2023 at 11:19AM ET.
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Buffalo at Jacksonville

November 7, 2021
img1:00 PM Eastern

Buffalo is a cold-weather team heading to the warm, humid Florida climate. They also have a division game on deck and are banged up on the offensive line. Guard Jon Feliciano (calf strain) is questionable along with left tackle Spencer Brown (back injury), who didn't play last week. This is their third road game in four contests, and they're a huge favorite. NFL road favorites that are outscoring opponents by 10+ on the season are 19-47 ATS after a win by 10+ points. Jacksonville prefers to run the football under first-year coach Urban Meyer, and the team gets No. 1 RB James Robinson back after he missed most of last week's game. Jacksonville is playing hard for this coaching staff, losing 24-21 at Cincinnati as a +7 dog, losing two home games by 10 and 12 points, along with an upset of Miami, 23-20. With the Bills 15-29 ATS off an AFC East win by 10+ points, plus 15-31 ATS off a home win against a division rival, back the huge home dog. Play Jacksonville.

Final Score

1
2
3
4
F
Buffalo Bills
3
3
0
0
6
Jacksonville Jaguars img
3
3
0
3
9
November 25, 2018 1:00pm ET
@
Jacksonville Jaguars
Jacksonville Jaguars
#251
Buffalo Bills
Buffalo Bills
#252

Lines & Odds

-3 (-120)
ATS
+3 (+100)
-163
Moneyline
+142
OVER 36.5 (-110)
Total
UNDER 36.5 (-110)

Public Consensus

Who was the public on? 59% of the public bets were on Jacksonville Jaguars on the -3 ATS. 54% of the public money was on Buffalo Bills to win on the moneyline. And, 53% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Jacksonville would win by a score of 19.8 to 16.8 with Jacksonville winning on the moneyline, Buffalo winning on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on November 24, 2023 at 10:54AM ET.
img NFL

Jacksonville at Buffalo

November 25, 2018
img1:00 PM Eastern

Here's a game even Jacksonville can't blow. The Jaguars dominated the Steelers for 3+ quarters last week, then collapsed again. But this team is loaded with talent on defense, one of the most dominating units in the NFL. Jacksonville is fourth in yards allowed, third against the pass, and ninth in points surrendered (21.9 pg). The Jaguars are 8-2-2 ATS after allowing 250+ yards passing in their previous game. They won't allow that to this one-dimensional and truly awful Buffalo offense, ranking #31 in yards, and last in passing and points (13.7 pg). And the defense is #19 in points allowed (25.1 pg). Buffalo has been outscored by -114 points, most in the league. Five quarterbacks have combined for five TDs to 16 picks! The Bills are 10-21 ATS after allowing fewer than 15 points in their previous game. It's hard to remember that Buffalo made the playoffs last season, losing 10-3 to this Jaguars team when the Bills actually had a semi-respectable QB (Tyrod Taylor). But an offseason fire sale has made them the NFL laughingstock of 2018 and the visitors will easily break their skid. Play Jacksonville.

Final Score

1
2
3
4
F
Jacksonville Jaguars
0
14
0
7
21
Buffalo Bills img
14
0
0
10
24

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