Previous Matchups & Picks

August 15, 2026 1:00pm ET
@
Carolina Panthers
Carolina Panthers
#121
Buffalo Bills
Buffalo Bills
#122

Lines & Odds

+2.5 (-105)
ATS
-2.5 (-115)
+130
Moneyline
-152
OVER 38.5 (-110)
Total
UNDER 38.5 (-110)

Panthers vs. Bills Spread Picks

Get this week's Panthers vs. Bills point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Panthers vs. Bills.

Computer Predictions

My computer prediction for this game was that Carolina would win by a score of 18.3 to 0.0, Carolina winning on the spread and the game going UNDER the total.

Pro Picks

This Pro Pick was released to clients on August 13, 2026 at 11:20AM ET.
img NFL

Carolina at Buffalo

August 15, 2026
img1:00 PM Eastern

Bryce Young gets his first preseason snaps of the year Saturday afternoon, with Dave Canales committing him to 10-20 reps after Carolina held him out of the Hall of Fame Game entirely. That's a real look at Carolina's actual starting quarterback. Buffalo counters with a coaching staff that's only confirmed one thing: defensive coordinator Jim Leonhard expects his starters to play. New head coach Joe Brady hasn't said the same for Josh Allen, and the growing expectation in Buffalo is that Allen sits this one out, handing the offense to Kyle Allen or Shane Buechele, who are still sorting out the backup job themselves. A game priced around this matchup's regular-season gap doesn't account for one team's true starting quarterback taking the field while the other's stays in sweats. Carolina is getting the better half of that trade, and the price hasn't caught up. Take the Panthers on the moneyline Saturday afternoon.

Final Score

1
2
3
4
F
Carolina Panthers
0
7
0
7
14
Buffalo Bills img
10
3
3
13
29

NFL Pro Pick Results

Here’s how my Pro Picks are performing.

NFLNFL All Picks last 25.0 years
Wins
Losses
Units
3,208
2,857
+182.36
NFLNFL Max Plays last 25.0 years
Wins
Losses
Units
1,320
1,125
+155.43
NFLNFL Free Picks last 16.6 years
Wins
Losses
Units
261
173
+99.53
NFLNFL All Preseason Picks last 24.0 years
Wins
Losses
Units
499
429
+46.95
NFLNFL All Playoff Picks last 13.1 years
Wins
Losses
Units
227
177
+42.81
October 26, 2025 1:00pm ET
@
Buffalo Bills
Buffalo Bills
#269
Carolina Panthers
Carolina Panthers
#270

Lines & Odds

-7 (-115)
ATS
+7 (-105)
-384
Moneyline
+302
OVER 48 (-110)
Total
UNDER 48 (-110)

Public Consensus

Who was the public on? 61% of the public bets were on Buffalo Bills on the -7 ATS. And, 59% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 26.8 to 20.3 with Buffalo winning on the moneyline, Carolina winning on the spread and the game going UNDER the total.

Pro Picks

This Pro Pick was released to clients on October 26, 2025 at 11:06AM ET.
img PARLAY

Buffalo (NFL-269) MONEYLINE + Philadelphia (NFL-272) MONEYLINE

October 26, 2025
img1:00 PM Eastern

Combine the Bills (-380) and the Eagles (-350) into a 2-team parlay at -160 odds.

Final Score

1
2
3
4
F
Buffalo Bills img
3
16
21
0
40
Carolina Panthers
0
3
0
6
9
August 24, 2024 1:00pm ET
@
Carolina Panthers
Carolina Panthers
#119
Buffalo Bills
Buffalo Bills
#120

Lines & Odds

-5.5 (-110)
ATS
+5.5 (-110)
-235
Moneyline
+194
OVER 30.5 (-110)
Total
UNDER 30.5 (-110)

Computer Predictions

My computer prediction for this game was that Carolina would win by a score of 17.5 to 13.5 with Carolina winning on the moneyline, Buffalo winning on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
Carolina Panthers img
7
10
8
6
31
Buffalo Bills
3
8
8
7
26
August 26, 2022 7:36pm ET
@
Buffalo Bills
Buffalo Bills
#109
Carolina Panthers
Carolina Panthers
#110

Lines & Odds

+5 (-110)
ATS
-5 (-110)
+188
Moneyline
-225
OVER 41 (-110)
Total
UNDER 41 (-110)

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 24.5 to 18.5 with Buffalo winning on the moneyline and on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on August 25, 2023 at 5:04PM ET.
img NFL

Buffalo at Carolina

August 26, 2022
img7:36 PM Eastern

Buffalo coach Sean McDermott is similar to John Harbough of the Ravens in that he likes to win preseason games. The Bills have won 10 preseason games in a row following their 42-15 rout of the Broncos last week as Josh Allen played a series and went three-for-three passing for 45 yards, including a 28-yard touchdown to Gabriel Davis, and Zach Moss and Duke Johnson each ran for two TDs. Case Keenum was 16 of 18 with no interceptions, and Matt Barkley completed seven of eight passes giving the Bills a lot of depth at the QB position. McDermott now is 12-5 straight up and 12-5 ATS in his preseason career, and Carolina coach Matt Ruhle is 2-3 SU and 2-2-1 ATS in his two years after splitting the first two games this year. The Panthers lost 20-10 to the Patriots with PJ Walker completing eight of 15 for 107 yards with two interceptions. . Carolina backup QB Matt Corral is out for the season. Take the Bills as a Max Play.

Final Score

1
2
3
4
F
Buffalo Bills
0
0
0
0
0
Carolina Panthers img
7
7
7
0
21
December 19, 2021 1:00pm ET
@
Carolina Panthers
Carolina Panthers
#307
Buffalo Bills
Buffalo Bills
#308

Lines & Odds

+14.5 (-110)
ATS
-14.5 (-110)
+598
Moneyline
-836
OVER 43 (-110)
Total
UNDER 43 (-110)

Public Consensus

Who was the public on? 63% of the public bets were on Buffalo Bills on the -14.5 ATS. And, 58% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Buffalo would win by a score of 27.6 to 15.7 with Buffalo winning on the moneyline, Carolina winning on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on December 15, 2023 at 2:04PM ET.
img NFL

Carolina at Buffalo

December 19, 2021
img1:00 PM Eastern

When Cam Newton arrived back in Carolina, it seemed to give the Panther's offense a much-needed boost. His first game was great as he declared he is back after scoring a TD. Things have really gone downhill after that game for the Panthers, and Newton hasn't just been ordinary, he has been awful. He enters this game with a QB rating of just 73.6. They have now also lost Christian McCaffrey for the season, and there is nowhere to turn. Buffalo has an elite defense, especially against weaker teams. The Buffalo QB is dealing with a toe injury and is listed as questionable, but I expect he will play, but how healthy is he if he doesn't. Carolina's defense is the best part of their team, and Buffalo has struggled scoring points as they have been held to 15 points or fewer in three of their last six games. Make the play on the UNDER.

Final Score

1
2
3
4
F
Carolina Panthers
0
8
0
6
14
Buffalo Bills img
0
17
7
7
31

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